Clinical, laboratory, and morphological characteristics of kidney damage in lymphoproliferative disorders
Джумабаева Б. Т., Бирюкова Л. С., Варшавский В. А., Марина С. А., Рошчина Л. С., Йулхакян У. Л., Столяревич Е. С.
Онкогематология
Т. 12, Вып. 1, С. 44-54
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17650/1818-8346-2017-12-1-44-54
Аннотация:
Kidney involvement in the onset of lymphoproliferative diseases (LPD) detected rarely, observed mainly at tumor progression or relapse. Objective: To determine the clinical and morphological features of kidney damage in the initial manifestation of LPD. Materials and methods: 19 patients with LPD and kidney damage were included in the study. The diagnosis of non-Hodgkin's lymphomas was established according to 2008 WHO classification. Histological and immunohistochemical, immunofluorescent and electron microscopic studies of nephrobiopsy have been performed. Results. Patients were aged 46-83 years (median 63 years), of which 13 were men and 6 women. Chronic lymphocytic leukemia / small cell lymphocytic lymphoma was established in 12 patients, marginal zone lymphoma - in 4 pts, follicular lymphoma - in 1 patient, Waldenstrom's macroglobulinemia - in 1 patient and diffuse large B-cell lymphoma (DLBCL) in 1 patient. Proteinuria was observed in 18 patients, microhematuria - in 6 pts, arter
Ключевые слова:
Bence-jones protein; Electron microscopic examination of kidney biopsy; Fibrillar glomerulonephritis; Free light chains; Glomerulopathy with minimal changes; Immunotactoid; Lymphoma; Mesangiocapillary; Mesangioproliferative
Язык текста: Русский
ISSN: 2413-4023
Джумабаева Б. Т.
Бирюкова Л. С.
Варшавский В. А. Владимир Анатольевич 1941-
Марина С. А.
Рошчина Л. С.
Йулхакян У. Л.
Столяревич Е. С.
Dzhumabaeva B. T.
Biryukova L. S.
Varshavskij V. A. Vladimir Anatolyevich 1941-
Marina S. A.
Roshchina L. S.
Julhakyan U. L.
Stolyarevich E. S.
Clinical, laboratory, and morphological characteristics of kidney damage in lymphoproliferative disorders
Текст визуальный непосредственный
Онкогематология
Издательский дом "АБВ-пресс"
Т. 12, Вып. 1 С. 44-54
2017
Статья
Bence-jones protein Electron microscopic examination of kidney biopsy Fibrillar glomerulonephritis Free light chains Glomerulopathy with minimal changes Immunotactoid Lymphoma Mesangiocapillary Mesangioproliferative
Kidney involvement in the onset of lymphoproliferative diseases (LPD) detected rarely, observed mainly at tumor progression or relapse. Objective: To determine the clinical and morphological features of kidney damage in the initial manifestation of LPD. Materials and methods: 19 patients with LPD and kidney damage were included in the study. The diagnosis of non-Hodgkin's lymphomas was established according to 2008 WHO classification. Histological and immunohistochemical, immunofluorescent and electron microscopic studies of nephrobiopsy have been performed. Results. Patients were aged 46-83 years (median 63 years), of which 13 were men and 6 women. Chronic lymphocytic leukemia / small cell lymphocytic lymphoma was established in 12 patients, marginal zone lymphoma - in 4 pts, follicular lymphoma - in 1 patient, Waldenstrom's macroglobulinemia - in 1 patient and diffuse large B-cell lymphoma (DLBCL) in 1 patient. Proteinuria was observed in 18 patients, microhematuria - in 6 pts, arter