Genetic and clinical predictors of treatment efficacy in depressive disorders
Иванец Н. Н., Кинкулькина М. А., Тихонова Ю. Г., Изумина Т. А., Авдеева Т. И., Морозов Д. И.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 117, Вып. 10, С. 55-64
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17116/jnevro201711710155-64
Аннотация:
Objective. To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders. Material and methods. The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used. Serotonin transporter 5-HTTLPR and STin2 and dopamine transporter 3',-VNTR polymorphisms were determined. Results and conclusion. The S-allele of the 5-HTTLPR polymorphism is associated with the low efficacy of treatment with selective serotonin reuptake inhibitors. Tricyclic antidepressants are more effective in treatment of psychogenic depression. The authors determined clinical factors that can predict response to treatment of psychogenic and endogenous depression. No predictors were found for organic depression. © 2017, Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
5-HTTLPR; Antidepressants; Depression; Efficacy; Individualized treatment; Pharmacogenetics; Predictors
dopamine transporter; serotonin transporter; serotonin uptake inhibitor; tricyclic antidepressant agent; dopamine transporter; serotonin transporter; SLC6A3 protein, human; SLC6A4 protein, human; Article; depression; depressive psychosis; gene frequency; genetic polymorphism; genetic trait; human; major clinical study; major depression; mental disease; psychometry; adult; allele; depression; female; genetics; major depression; male; middle aged; psychological rating scale; treatment outcome; Adult; Alleles; Antidepressive Agents, Tricyclic; Depressive Disorder; Depressive Disorder, Major; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales; Psychometrics; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Treatment Outcome
Язык текста: Русский
ISSN: 2309-4729
Иванец Н. Н. Николай Николаевич 1941-
Кинкулькина М. А. Марина Аркадьевна 1966-
Тихонова Ю. Г. Юлия Гулямовна 1979-
Изумина Т. А.
Авдеева Т. И. Татьяна Ивановна 1975-
Морозов Д. И.
Ivanets N. N. Nikolay Nikolaevich 1941-
Kinkul`kina M. A. Marina Arkadyevna 1966-
Tikhonova Yu. G. Yuliya Gulyamovna 1979-
Izumina T. A.
Avdeeva T. I. Tat`yana Ivanovna 1975-
Morozov D. I.
Genetic and clinical predictors of treatment efficacy in depressive disorders
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 117, Вып. 10 С. 55-64
2017
Статья
5-HTTLPR Antidepressants Depression Efficacy Individualized treatment Pharmacogenetics Predictors
dopamine transporter serotonin transporter serotonin uptake inhibitor tricyclic antidepressant agent dopamine transporter serotonin transporter SLC6A3 protein, human SLC6A4 protein, human Article depression depressive psychosis gene frequency genetic polymorphism genetic trait human major clinical study major depression mental disease psychometry adult allele depression female genetics major depression male middle aged psychological rating scale treatment outcome Adult Alleles Antidepressive Agents, Tricyclic Depressive Disorder Depressive Disorder, Major Dopamine Plasma Membrane Transport Proteins Female Humans Male Middle Aged Polymorphism, Genetic Psychiatric Status Rating Scales Psychometrics Serotonin Plasma Membrane Transport Proteins Serotonin Uptake Inhibitors Treatment Outcome
Objective. To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders. Material and methods. The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used. Serotonin transporter 5-HTTLPR and STin2 and dopamine transporter 3',-VNTR polymorphisms were determined. Results and conclusion. The S-allele of the 5-HTTLPR polymorphism is associated with the low efficacy of treatment with selective serotonin reuptake inhibitors. Tricyclic antidepressants are more effective in treatment of psychogenic depression. The authors determined clinical factors that can predict response to treatment of psychogenic and endogenous depression. No predictors were found for organic depression. © 2017, Media Sphera Publishing Group. All rights reserved.