Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus
Бурчаков Д. И., Майоров А. Ю.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 117, Вып. 10, С. 16-21
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17116/jnevro201711710116-21
Аннотация:
Objectives. To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). Material and methods. In this cross-sectional study 183 patients with HbAc1≥7[%] underwent three-channel overnight monitoring (ApneaLink) and completed Berlin Questionnaire, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Patients were divided in two groups, based on the cut-off value of oxygen desaturation index≥15. Results and conclusion. There were 79 (43[%]) patients with intermittent hypoxia, which was associated with poorer glycaemic control, defined as HbA1c>8.7[%] (sample median) in the univariate analysis and after adjustment for body mass index OR 2,40 (CI 1.21—4.95, p=0.021). Neither of three questionnaires yielded satisfactory results as a screening method in patients with T2DM. There is a need to implement instrumental screening of sleep-disordered breathing in this population and to study the effec
Ключевые слова:
Intermittent hypoxia; Obstructive sleep apnea syndrome; Type 2 diabetes mellitus
hemoglobin A1c; antidiabetic agent; glycosylated hemoglobin; Article; body mass; carbohydrate metabolism; cross-sectional study; Epworth sleepiness scale; glycemic control; human; intermittent hypoxia; major clinical study; non insulin dependent diabetes mellitus; oxygen desaturation; Pittsburgh Sleep Quality Index; positive end expiratory pressure; questionnaire; sleep disordered breathing; blood; complication; drug effects; female; glucose blood level; hyperglycemia; hypoxia; male; middle aged; non insulin dependent diabetes mellitus; polysomnography; sleep disordered breathing; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin A; Humans; Hyperglycemia; Hypoglycemic Agents; Hypoxia; Male; Middle Aged; Polysomnography; Sleep Apnea Syndromes; Surveys and Questionnaires
Язык текста: Русский
ISSN: 2309-4729
Бурчаков Д. И. Денис Игоревич 1985-
Майоров А. Ю. Александр Юрьевич 1964-
Burchakov D. I. Denis Igorevich 1985-
Mayorov A. Yu. Aleksandr Yuryevich 1964-
Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 117, Вып. 10 С. 16-21
2017
Статья
Intermittent hypoxia Obstructive sleep apnea syndrome Type 2 diabetes mellitus
hemoglobin A1c antidiabetic agent glycosylated hemoglobin Article body mass carbohydrate metabolism cross-sectional study Epworth sleepiness scale glycemic control human intermittent hypoxia major clinical study non insulin dependent diabetes mellitus oxygen desaturation Pittsburgh Sleep Quality Index positive end expiratory pressure questionnaire sleep disordered breathing blood complication drug effects female glucose blood level hyperglycemia hypoxia male middle aged non insulin dependent diabetes mellitus polysomnography sleep disordered breathing Blood Glucose Body Mass Index Cross-Sectional Studies Diabetes Mellitus, Type 2 Female Glycated Hemoglobin A Humans Hyperglycemia Hypoglycemic Agents Hypoxia Male Middle Aged Polysomnography Sleep Apnea Syndromes Surveys and Questionnaires
Objectives. To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). Material and methods. In this cross-sectional study 183 patients with HbAc1≥7[%] underwent three-channel overnight monitoring (ApneaLink) and completed Berlin Questionnaire, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Patients were divided in two groups, based on the cut-off value of oxygen desaturation index≥15. Results and conclusion. There were 79 (43[%]) patients with intermittent hypoxia, which was associated with poorer glycaemic control, defined as HbA1c>8.7[%] (sample median) in the univariate analysis and after adjustment for body mass index OR 2,40 (CI 1.21—4.95, p=0.021). Neither of three questionnaires yielded satisfactory results as a screening method in patients with T2DM. There is a need to implement instrumental screening of sleep-disordered breathing in this population and to study the effec