Regeneration Potential of Lymphoid Tissue of Small Intestine in Mice after Exposure to Low-Intensity Radiation
Klochkova S. V., Kvaratskheliya A. G., Alekseeva N. T., Nikituk D. B.
Bulletin of Experimental Biology and Medicine
Vol.164, Issue2, P. 214-217
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.1007/s10517-017-3961-1
Аннотация:
Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. Significant changes were observed in the lymphoid system of the small intestine after exposure to low-intensity radiation. The size of aggregated lymphoid nodules decreased and the relative number of cells with degenerative changes increased. Regenerative processes were observed as soon as on day 4 of the rehabilitation period. However, the number and sizes of aggregated lymphoid nodules (length, width, and section area), and the ratio of lymphoid nodules with germinal center were still lower than in the control. The number of cells forming lymphoid interstitial plaques was close to the control on days 28-90 of the rehabilitation process. © 2017, Springer Science+Business M
Ключевые слова:
aggregated lymphoid nodules; radiation; small intestine; space flight factors
cesium 137; cesium; Cesium-137; animal cell; animal experiment; Article; controlled study; germinal center; long term exposure; low energy radiation; lymph node; lymphatic system; lymphoid tissue; male; morphology; morphometry; mouse; nonhuman; radiation exposure; small intestine; tissue regeneration; animal; C57BL mouse; CBA mouse; cross breeding; experimental radiation injury; gamma radiation; immunology; pathology; radiation response; regeneration; small intestine; Animals; Cesium Radioisotopes; Crosses, Genetic; Gamma Rays; Intestine, Small; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Radiation Injuries, Experimental; Regeneration
Язык текста: Английский
ISSN: 1573-8221
Klochkova S. V. Svetlana Valeryevna 1968-
Kvaratskheliya A. G.
Alekseeva N. T.
Nikituk D. B. Dmitrij Borisovich 1962-
Клочкова С. В. Светлана Валерьевна 1968-
Кварацхелия А. Г.
Алексеева Н. Т.
Никитюк Д. Б. Дмитрий Борисович 1962-
Regeneration Potential of Lymphoid Tissue of Small Intestine in Mice after Exposure to Low-Intensity Radiation
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.164, Issue2 P. 214-217
2017
Статья
aggregated lymphoid nodules radiation small intestine space flight factors
cesium 137 cesium Cesium-137 animal cell animal experiment Article controlled study germinal center long term exposure low energy radiation lymph node lymphatic system lymphoid tissue male morphology morphometry mouse nonhuman radiation exposure small intestine tissue regeneration animal C57BL mouse CBA mouse cross breeding experimental radiation injury gamma radiation immunology pathology radiation response regeneration small intestine Animals Cesium Radioisotopes Crosses, Genetic Gamma Rays Intestine, Small Lymph Nodes Male Mice Mice, Inbred C57BL Mice, Inbred CBA Radiation Injuries, Experimental Regeneration
Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. Significant changes were observed in the lymphoid system of the small intestine after exposure to low-intensity radiation. The size of aggregated lymphoid nodules decreased and the relative number of cells with degenerative changes increased. Regenerative processes were observed as soon as on day 4 of the rehabilitation period. However, the number and sizes of aggregated lymphoid nodules (length, width, and section area), and the ratio of lymphoid nodules with germinal center were still lower than in the control. The number of cells forming lymphoid interstitial plaques was close to the control on days 28-90 of the rehabilitation process. © 2017, Springer Science+Business M