Evaluation of the effectiveness of a nonsteroidal anti-inflammatory drug (NSAID) selection algorithm based on the analysis of risk factors for...
Каратеев А. Е., Лила А. М., Чурюканов М. В., Скоробогатых К. В., Амелин А. В., Захаров Д. В., Трофимов Е. А., Широков В. А., Попова Т. В., Шестел Е. А., Гончарова З. А., Куликов А. И., Несмеянова О. Б., Галиханова М. В.
Научно-практическая ревматология
Т. 55, Вып. 5, С. 485-492
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.14412/1995-4484-2017-485-492
Аннотация:
To enhance the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs), a class of essential medications used to treat acute and chronic pain, is an important and urgent task. For its solution, in 2015 Russian experts provided an NSAID selection algorithm based on the assessment of risk factors (RFs) for drug-induced complications and on the prescription of drugs with the least negative effect on the gastrointestinal tract and cardiovascular system. The PRINCIPLE project was implemented to test the effectiveness of this algorithm. Subjects and methods. A study group consisted of 439 patients (65[%] were women and 35[%] - men; their mean age was 51.3±14.4 years) with severe musculoskeletal pain, who were prescribed NSAIDs by using the above algorithm. The majority of patients were noted to have RFs: gastrointestinal and cardiovascular ones in 62 and 88[%] of the patients, respectively. Given the R F, eight NSAIDs were used; these were aceclofenac, diclofenac, ibuprofen, ketoprofe
Ключевые слова:
Clinical guidelines; Efficacy; Nonsteroidal anti-inflammatory drugs; Safety; Selection algorithm
Язык текста: Русский
ISSN: 1995-4492
Каратеев А. Е.
Лила А. М.
Чурюканов М. В. Максим Валерьевич 1982-
Скоробогатых К. В. Кирилл Владимирович 1980-
Амелин А. В. Алексей Вадимович 1996-
Захаров Д. В.
Трофимов Е. А.
Широков В. А.
Попова Т. В.
Шестел Е. А.
Гончарова З. А.
Куликов А. И.
Несмеянова О. Б.
Галиханова М. В.
Karateev A. E.
Lila A. M.
Churyukanov M. V. Maksim Valeryevich 1982-
Skorobogaty'kh K. V. Kirill Vladimirovich 1980-
Amelin A. V. Aleksej Vadimovich 1996-
Zakharov D. V.
Trofimov E. A.
Shirokov V. A.
Popova T. V.
Shestel E. A.
Goncharova Z. A.
Kulikov A. I.
Nesmeyanova O. B.
Galikhanova M. V.
Evaluation of the effectiveness of a nonsteroidal anti-inflammatory drug (NSAID) selection algorithm based on the analysis of risk factors for drug-induced complications in real clinical practice: The results of the all-Russian principle project (application of recommendations for NSAID use: A goal-oriented change of practice)
Evaluation of the effectiveness of a nonsteroidal anti-inflammatory drug (NSAID) selection algorithm based on the analysis of risk factors for...
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 55, Вып. 5 С. 485-492
2017
Статья
Clinical guidelines Efficacy Nonsteroidal anti-inflammatory drugs Safety Selection algorithm
To enhance the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs), a class of essential medications used to treat acute and chronic pain, is an important and urgent task. For its solution, in 2015 Russian experts provided an NSAID selection algorithm based on the assessment of risk factors (RFs) for drug-induced complications and on the prescription of drugs with the least negative effect on the gastrointestinal tract and cardiovascular system. The PRINCIPLE project was implemented to test the effectiveness of this algorithm. Subjects and methods. A study group consisted of 439 patients (65[%] were women and 35[%] - men; their mean age was 51.3±14.4 years) with severe musculoskeletal pain, who were prescribed NSAIDs by using the above algorithm. The majority of patients were noted to have RFs: gastrointestinal and cardiovascular ones in 62 and 88[%] of the patients, respectively. Given the R F, eight NSAIDs were used; these were aceclofenac, diclofenac, ibuprofen, ketoprofe