Anti-inflammatory therapy for atherosclerosis: Contribution to and lessons of rheumatology

According to modern views, chronic low-grade inflammation, the development of which is associated with the uncontrolled activation of both innate and acquired immunity, plays a fundamental role at all stages of the atherosclerotic process. The contribution of inflammation to the development of an atherosclerotic vascular lesion drew attention to the similarity of the mechanisms in the immunopathogenesis of atherosclerosis and the classic immunoinflammatory disease (IID) - rheumatoid arthritis (RA). Interleukin 1(3 (IL-1p), which plays an important role in the development of many acute and chronic IIDs, is of particular interest with regard to its implication in the pathogenesis of an atherosclerotic vascular lesion and as a promising therapeutic target. The atherosclerosis development mechanisms related to IL-1(3 determine the ability of cholesterol crystals and other proatherogenic factors to induce IL-1β synthesis due to NLRP3 inflammasome activation. There is strong evidence that in