Antibiotic resistance and its molecular mechanisms in carbapenem-nonsusceptible Klebsiella pneumoniae isolated in pediatric ICUs in Moscow
Крyжановскайа О. А., Иазарева А. В., Алябиева Н. М., Тепаев Р. Ф., Карасева О. В., Чеботар И. В., Маянский Н. А.
Антибиотики и химиотерапия
Т. 61, Вып. 7-8, С. 22-26
Опубликовано: 2016
Тип ресурса: Обзор
Аннотация:
Klebsiella pneumoniae is a significant pathogen associated with hospital infections. Its was isolated in intensive care units (ICU) at two pediatric hospitals in Moscow in 2012-2014 from 41[%] (387/935) of the patients. The rate of carbapenem-nonsusceptibility (Carba-NS) amounted to 25[%] for imipenem and 27[%] for meropenem. For further analyses, 67 isolates were selected, including 57 Carba-NS and 10 Carba-susceptible (Carba-S). Among the isolates, 100[%] was nonsusceptible to the III-IV generation cephalosporins, 50-84[%] was resistant to aminoglycosides. The rate of nonsusceptibility to ciprofloxacin and phosphomycin exceeded 90[%]. All the tested Carba-S K.pneumoniae isolates were susceptible to tigecycline, whereas 25[%] of the Carba-NS isolates was tigecycline-NS. The prevalence of the colistin-NS isolates was the same in Carba-S (20[%]) and Carba-NS (26[%]) bacteria. The blaCTX-M gene was carried by 100[%] of the Carba-S isolates, combining with the blaTEM gene in 60[%] of the isolates. In 89[%] of th
Ключевые слова:
Antibiotic resistance; Carbapenemase; Klebsiella pneumoniae; OXA-48
aminoglycoside; antiinfective agent; bacterial protein; beta lactamase; carbapenem derivative; carbapenemase; cephalosporin derivative; colistin; isoenzyme; minocycline; tigecycline; adolescent; analogs and derivatives; child; clinical trial; cross infection; drug effects; enzymology; female; gene expression; genetics; growth, development and aging; hospital; human; intensive care unit; Klebsiella infection; Klebsiella pneumoniae; male; metabolism; microbial sensitivity test; microbiology; multicenter study; multidrug resistance; Russian Federation; Adolescent; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Cephalosporins; Child; Colistin; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Gene Expression; Hospitals, Pediatric; Humans; Intensive Care Units; Isoenzymes; Klebsiella Infections; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Minocycline; Moscow
Язык текста: Русский
ISSN: 0235-2990
Крyжановскайа О. А.
Иазарева А. В.
Алябиева Н. М.
Тепаев Р. Ф. Рустэм Фаридович 1964-
Карасева О. В.
Чеботар И. В.
Маянский Н. А. Николай Андреевич 1972-
Kryzhanovskaya O. A.
Iazareva A. V.
Alyabieva N. M.
Tepaev R. F. Ruste`m Faridovich 1964-
Karaseva O. V.
Chebotar I. V.
Mayanskij N. A. Nikolay Andreevich 1972-
Antibiotic resistance and its molecular mechanisms in carbapenem-nonsusceptible Klebsiella pneumoniae isolated in pediatric ICUs in Moscow
Текст визуальный непосредственный
Антибиотики и химиотерапия
Издательство ОКИ
Т. 61, Вып. 7-8 С. 22-26
2016
Обзор
Antibiotic resistance Carbapenemase Klebsiella pneumoniae OXA-48
aminoglycoside antiinfective agent bacterial protein beta lactamase carbapenem derivative carbapenemase cephalosporin derivative colistin isoenzyme minocycline tigecycline adolescent analogs and derivatives child clinical trial cross infection drug effects enzymology female gene expression genetics growth, development and aging hospital human intensive care unit Klebsiella infection Klebsiella pneumoniae male metabolism microbial sensitivity test microbiology multicenter study multidrug resistance Russian Federation Adolescent Aminoglycosides Anti-Bacterial Agents Bacterial Proteins beta-Lactamases Carbapenems Cephalosporins Child Colistin Cross Infection Drug Resistance, Multiple, Bacterial Female Gene Expression Hospitals, Pediatric Humans Intensive Care Units Isoenzymes Klebsiella Infections Klebsiella pneumoniae Male Microbial Sensitivity Tests Minocycline Moscow
Klebsiella pneumoniae is a significant pathogen associated with hospital infections. Its was isolated in intensive care units (ICU) at two pediatric hospitals in Moscow in 2012-2014 from 41[%] (387/935) of the patients. The rate of carbapenem-nonsusceptibility (Carba-NS) amounted to 25[%] for imipenem and 27[%] for meropenem. For further analyses, 67 isolates were selected, including 57 Carba-NS and 10 Carba-susceptible (Carba-S). Among the isolates, 100[%] was nonsusceptible to the III-IV generation cephalosporins, 50-84[%] was resistant to aminoglycosides. The rate of nonsusceptibility to ciprofloxacin and phosphomycin exceeded 90[%]. All the tested Carba-S K.pneumoniae isolates were susceptible to tigecycline, whereas 25[%] of the Carba-NS isolates was tigecycline-NS. The prevalence of the colistin-NS isolates was the same in Carba-S (20[%]) and Carba-NS (26[%]) bacteria. The blaCTX-M gene was carried by 100[%] of the Carba-S isolates, combining with the blaTEM gene in 60[%] of the isolates. In 89[%] of th