Pressure for pattern-specific intertypic recombination between sabin polioviruses: Evolutionary implications
Korotkova E., Laassri M., Zagorodnyaya T., Petrovskaya S., Rodionova E., Cherkasova E., Gmy'l` A. P., Ivanova O. E., Eremeeva T. P., Lipskaya G. Y., Agol V. I., Chumakov K.
Viruses
Vol.9, Issue11, Num.353
Опубликовано: 2017
Тип ресурса: Статья
Аннотация:
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These “weak” segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also
Ключевые слова:
Attenuation; Reversion; Vaccine-derived polioviruses; Vaccine-induced adverse reactions; Virulence
oral poliomyelitis vaccine; protein VP1; RNA directed RNA polymerase; virus RNA; oral poliomyelitis vaccine; Article; bioinformatics; biological accident; Enterovirus; evolution; flaccid paralysis; gene mutation; gene sequence; genetic recombination; genetic stability; nonhuman; nucleotide sequence; Poliomyelitis virus; polymerase chain reaction; sequence homology; serotype; virus attenuation; virus strain; adverse drug reaction; Enterovirus infection; genetics; human; molecular evolution; mutation; poliomyelitis; Poliomyelitis virus; virology; virulence; virus genome; Drug-Related Side Effects and Adverse Reactions; Enterovirus Infections; Evolution, Molecular; Genome, Viral; Humans; Mutation; Poliomyelitis; Poliovirus; Poliovirus Vaccine, Oral; Recombination, Genetic; Virulence
Язык текста: Английский
ISSN: 1999-4915
Korotkova E.
Laassri M.
Zagorodnyaya T.
Petrovskaya S.
Rodionova E.
Cherkasova E.
Gmy'l` A. P. Anatolij Petrovich 1966-
Ivanova O. E. Ol`ga Evgenyevna 1955-
Eremeeva T. P.
Lipskaya G. Y.
Agol V. I.
Chumakov K.
Короткова Е.
Лаассри М.
Загороднyайа Т.
Петровскайа С.
Родионова Е.
Черкасова Е.
Гмыль А. П. Анатолий Петрович 1966-
Иванова О. Е. Ольга Евгеньевна 1955-
Еремеева Т. П.
Липскайа Г. Y.
Агол В. И.
Чумаков К.
Pressure for pattern-specific intertypic recombination between sabin polioviruses: Evolutionary implications
Текст визуальный непосредственный
Viruses
Vol.9, Issue11 Num.353
2017
Статья
Attenuation Reversion Vaccine-derived polioviruses Vaccine-induced adverse reactions Virulence
oral poliomyelitis vaccine protein VP1 RNA directed RNA polymerase virus RNA oral poliomyelitis vaccine Article bioinformatics biological accident Enterovirus evolution flaccid paralysis gene mutation gene sequence genetic recombination genetic stability nonhuman nucleotide sequence Poliomyelitis virus polymerase chain reaction sequence homology serotype virus attenuation virus strain adverse drug reaction Enterovirus infection genetics human molecular evolution mutation poliomyelitis Poliomyelitis virus virology virulence virus genome Drug-Related Side Effects and Adverse Reactions Enterovirus Infections Evolution, Molecular Genome, Viral Humans Mutation Poliomyelitis Poliovirus Poliovirus Vaccine, Oral Recombination, Genetic Virulence
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These “weak” segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also