Persistent virus presence during experimental oncolytic virus therapy in the model of subcutaneous mouse xenografts of human glyobolastoma multiforme
Zheltukhin A. O., Sidorenko A. S., Kriukova K. K., Golbin D. A., Tereshkova A. V.
Journal of Pharmaceutical Sciences and Research
Vol.9, Issue11, P. 2224-2226
Опубликовано: 2017
Тип ресурса: Статья
Аннотация:
The approach of using oncolytic viruses for the therapy of malignant diseases is considered as a promising alternative to cytotoxic chemotherapy. Especially relevant is the development of new therapies in the case of malignant glioblastomas, a disease against which effective treatments have not been developed to date. Viruses of many different families demonstrate selective activity against glioblastoma cells. In particular, a pronounced lytic activity against glioblastomas demonstrate nonpathogenic or vaccine strains of human enteroviruses. The main mechanism of oncolytic action of enteroviruses is associated with their ability to selectively replicate in tumor cells, although stimulation of the immune system also contributes to the oncolytic effect. The objective of the study was to determine the possibility of effective delivery of oncolytic enterovirus (vaccine strain type 1 poliovirus) to the subcutaneous xenografts of the human glioblastoma cell line (U87MG) and to determine the
Ключевые слова:
Athymic mice; Experimental therapy; Multiform glioblastoma; Poliovirus; Viral oncolysis; Xenografts of tumors
animal experiment; Article; controlled study; glioblastoma; human; human cell; Human poliovirus 1; mouse; nonhuman; oncolytic virotherapy; tumor volume; virus detection; virus particle
Язык текста: Английский
ISSN: 0975-1459
Zheltukhin A. O.
Sidorenko A. S.
Kriukova K. K.
Golbin D. A.
Tereshkova A. V.
Желтюхин А. О.
Сидоренко А. С.
Криукова К. К.
Голбин Д. А.
Терешкова А. В.
Persistent virus presence during experimental oncolytic virus therapy in the model of subcutaneous mouse xenografts of human glyobolastoma multiforme
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.9, Issue11 P. 2224-2226
2017
Статья
Athymic mice Experimental therapy Multiform glioblastoma Poliovirus Viral oncolysis Xenografts of tumors
animal experiment Article controlled study glioblastoma human human cell Human poliovirus 1 mouse nonhuman oncolytic virotherapy tumor volume virus detection virus particle
The approach of using oncolytic viruses for the therapy of malignant diseases is considered as a promising alternative to cytotoxic chemotherapy. Especially relevant is the development of new therapies in the case of malignant glioblastomas, a disease against which effective treatments have not been developed to date. Viruses of many different families demonstrate selective activity against glioblastoma cells. In particular, a pronounced lytic activity against glioblastomas demonstrate nonpathogenic or vaccine strains of human enteroviruses. The main mechanism of oncolytic action of enteroviruses is associated with their ability to selectively replicate in tumor cells, although stimulation of the immune system also contributes to the oncolytic effect. The objective of the study was to determine the possibility of effective delivery of oncolytic enterovirus (vaccine strain type 1 poliovirus) to the subcutaneous xenografts of the human glioblastoma cell line (U87MG) and to determine the