Regulatory Profile Changes of Lymphocytes and Peripheral Blood Monocytes in Children with Candidiasis Associated with Chronic Somatic Diseases
Agafonova E. V., Rizvanova F. F., Kadyrova A. E., Abrahamyan L.
BioNanoScience
Vol.7, Issue4, P. 627-632
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.1007/s12668-017-0430-2
Аннотация:
In this paper, we report results of the study of immune parameters with the assessment of regulatory and effector subpopulations of lymphocytes and monocytes with candidiasis in children with chronic somatic diseases (secondary pyelonephritis and obstructive diseases of the upper gastrointestinal tract). Candidiasis was diagnosed by the rising level of circulating Candida albicans mannan antigen and culture mycological research. It was found that the persistence of fungi is associated with differentiated regulatory changes in the structure of subpopulations of lymphocytes and monocytes with preferential increase of immunosuppressive cells (CD4+CD25+hi, CD3+CD16/56+, CD3−CD8+, CD3+4 amid reduction of effector subpopulations of lymphocytes and antigen presenting cells associated with Th1 immune response profile. © 2017, Springer Science+Business Media, LLC.
Ключевые слова:
Candidiasis; Chronic somatic diseases; Subpopulation of lymphocytes and monocytes
Antigens; Body fluids; Lymphocytes; Antigen presenting cells; Candida albicans; Candidiasis; Peripheral blood; Regulatory change; Somatic disease; Subpopulation of lymphocytes and monocytes; Upper gastrointestinal; T-cells; CD16 antigen; CD3 antigen; CD4 antibody; CD4 antigen; CD56 antigen; CD8 antigen; interleukin 2 receptor alpha; adolescent; Article; candidiasis; cell subpopulation; child; chronic obstructive lung disease; flow cytometry; Helicobacter infection; human; immune response; lymphocyte; monocyte; preschool child; pyelonephritis; regulatory mechanism; school child
Язык текста: Английский
ISSN: 2191-1649
Agafonova E. V.
Rizvanova F. F.
Kadyrova A. E.
Abrahamyan L.
Агафонова Е. В.
Ризванова Ф. Ф.
Кадyрова А. Е.
Абрахамян Л.
Regulatory Profile Changes of Lymphocytes and Peripheral Blood Monocytes in Children with Candidiasis Associated with Chronic Somatic Diseases
Текст визуальный непосредственный
BioNanoScience
Vol.7, Issue4 P. 627-632
2017
Статья
Candidiasis Chronic somatic diseases Subpopulation of lymphocytes and monocytes
Antigens Body fluids Lymphocytes Antigen presenting cells Candida albicans Candidiasis Peripheral blood Regulatory change Somatic disease Subpopulation of lymphocytes and monocytes Upper gastrointestinal T-cells CD16 antigen CD3 antigen CD4 antibody CD4 antigen CD56 antigen CD8 antigen interleukin 2 receptor alpha adolescent Article candidiasis cell subpopulation child chronic obstructive lung disease flow cytometry Helicobacter infection human immune response lymphocyte monocyte preschool child pyelonephritis regulatory mechanism school child
In this paper, we report results of the study of immune parameters with the assessment of regulatory and effector subpopulations of lymphocytes and monocytes with candidiasis in children with chronic somatic diseases (secondary pyelonephritis and obstructive diseases of the upper gastrointestinal tract). Candidiasis was diagnosed by the rising level of circulating Candida albicans mannan antigen and culture mycological research. It was found that the persistence of fungi is associated with differentiated regulatory changes in the structure of subpopulations of lymphocytes and monocytes with preferential increase of immunosuppressive cells (CD4+CD25+hi, CD3+CD16/56+, CD3−CD8+, CD3+4 amid reduction of effector subpopulations of lymphocytes and antigen presenting cells associated with Th1 immune response profile. © 2017, Springer Science+Business Media, LLC.