Journal of General Virology
Vol.98, Issue12, Num.000966
Аннотация:
Non-polio enteroviruses are a ubiquitous and divergent group of non-enveloped RNA viruses. Novel types are reported regularly in addition to over 100 known types; however, mechanisms of emergence of novel types remain obscure. Here, the 33 most common types represented by 35–629 non-redundant partial VP1 sequences in GenBank were studied in parallel using Bayesian coalescent molecular clock analysis to investigate common evolutionary trends among enterovirus types. Inferred substitution rates were in the range of 0.41×10-2 to 3.07×10-2 substitutions per site per year. The most recent common ancestors of known isolates of each type presumably existed between 55 and 200 years ago. Phylogenetic analysis results suggested that global type populations underwent bottlenecks that could repeatedly reset the common ancestor dates. Nevertheless, species-level analysis suggested that the contemporary enterovirus types emerged within the last millennium. Analysis of 2657 complete VP1 sequences of
Ключевые слова:
Capsid; Emerging infection; Evolution; Serotype; Taxonomy
amino acid; nucleotide; capsid protein; amino acid sequence; Article; Enterovirus; genotype; geographic distribution; molecular clock; molecular evolution; non polio enterovirus; nonhuman; nucleotide sequence; phylogenetic tree; phylogeny; priority journal; sequence analysis; Bayes theorem; classification; Enterovirus; Enterovirus infection; genetic variation; genetics; human; molecular epidemiology; mutation rate; phylogeny; sequence alignment; virology; virus genome; Amino Acid Sequence; Base Sequence; Bayes Theorem; Capsid Proteins; Enterovirus; Enterovirus Infections; Evolution, Molecular; Genetic Variation; Genome, Viral; Genotype; Humans; Molecular Epidemiology; Mutation Rate; Phylogeny; Sequence Alignment
Lukashev A. N. Aleksandr Nikolaevich 1977-
Vakulenko Yu. A. Yuliya Aleksandrovna 1994-
Лукашев А. Н. Александр Николаевич 1977-
Вакуленко Ю. А. Юлия Александровна 1994-
Molecular evolution of types in non-polio enteroviruses
Текст визуальный непосредственный
Journal of General Virology
Society for General Microbiology
Vol.98, Issue12 Num.000966
2017
Статья
Capsid Emerging infection Evolution Serotype Taxonomy
amino acid nucleotide capsid protein amino acid sequence Article Enterovirus genotype geographic distribution molecular clock molecular evolution non polio enterovirus nonhuman nucleotide sequence phylogenetic tree phylogeny priority journal sequence analysis Bayes theorem classification Enterovirus Enterovirus infection genetic variation genetics human molecular epidemiology mutation rate phylogeny sequence alignment virology virus genome Amino Acid Sequence Base Sequence Bayes Theorem Capsid Proteins Enterovirus Enterovirus Infections Evolution, Molecular Genetic Variation Genome, Viral Genotype Humans Molecular Epidemiology Mutation Rate Phylogeny Sequence Alignment
Non-polio enteroviruses are a ubiquitous and divergent group of non-enveloped RNA viruses. Novel types are reported regularly in addition to over 100 known types; however, mechanisms of emergence of novel types remain obscure. Here, the 33 most common types represented by 35–629 non-redundant partial VP1 sequences in GenBank were studied in parallel using Bayesian coalescent molecular clock analysis to investigate common evolutionary trends among enterovirus types. Inferred substitution rates were in the range of 0.41×10-2 to 3.07×10-2 substitutions per site per year. The most recent common ancestors of known isolates of each type presumably existed between 55 and 200 years ago. Phylogenetic analysis results suggested that global type populations underwent bottlenecks that could repeatedly reset the common ancestor dates. Nevertheless, species-level analysis suggested that the contemporary enterovirus types emerged within the last millennium. Analysis of 2657 complete VP1 sequences of