Microneedles as the technique of drug delivery enhancement in diverse organs and tissues
Rzhevskij A. S., Singh T. R. R., Donnelly R. F., Anissimov Yu. G.
Journal of Controlled Release
Vol.270, P. 184-202
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.1016/j.jconrel.2017.11.048
Аннотация:
Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and hydrogel forming microneedles. In their turn, the modifications have resulted in new mechanisms of drug delivery enhancement and followed by the expansion of applicability range in terms of targeted tissues and organs. Thus, in addition to percutaneous drug delivery, microneedles have been considered as an efficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vaginal drug administration. It is anticipated that the technique of microneedle-assisted drug delivery will soon become relevant for majority of organs and tissues. © 2017 Elsevier B.V.
Ключевые слова:
Gastrointestinal drug delivery; Microneedles; Ocular drug delivery; Oral mucosal drug delivery; Trans-ungual drug delivery; Transdermal drug delivery
Controlled drug delivery; Histology; Needles; Tissue; Drug administration; Gastrointestinal drugs; Microneedles; New mechanisms; Ocular drug delivery; Stratum corneum; Topical drug deliveries; Transdermal drug delivery; Targeted drug delivery; cosmetic; drug carrier; insulin; vaccine; drug delivery system; eye; gastrointestinal tract; human; intraocular drug administration; intravaginal drug administration; molecular weight; mouth cancer; mouth cavity; nonhuman; organ; percutaneous drug delivery; priority journal; Review; skin permeability; tissues; transdermal drug administration; vaccination; animal; drug administration route; microinjection; needle; Animals; Drug Administration Routes; Drug Delivery Systems; Humans; Microinjections; Needles
Язык текста: Английский
ISSN: 1873-4995
Rzhevskij A. S. Aleksej Sergeevich 1991-
Singh T. R. R.
Donnelly R. F.
Anissimov Yu. G. Yurij German 1965-
Ржевский А. С. Алексей Сергеевич 1991-
Сингх Т. Р. Р.
Доннеллy Р. Ф.
Аниссимов Ю. Г. Юрий Герман 1965-
Microneedles as the technique of drug delivery enhancement in diverse organs and tissues
Текст визуальный непосредственный
Journal of Controlled Release
Elsevier Science Publisher B.V.
Vol.270 P. 184-202
2018
Обзор
Gastrointestinal drug delivery Microneedles Ocular drug delivery Oral mucosal drug delivery Trans-ungual drug delivery Transdermal drug delivery
Controlled drug delivery Histology Needles Tissue Drug administration Gastrointestinal drugs Microneedles New mechanisms Ocular drug delivery Stratum corneum Topical drug deliveries Transdermal drug delivery Targeted drug delivery cosmetic drug carrier insulin vaccine drug delivery system eye gastrointestinal tract human intraocular drug administration intravaginal drug administration molecular weight mouth cancer mouth cavity nonhuman organ percutaneous drug delivery priority journal Review skin permeability tissues transdermal drug administration vaccination animal drug administration route microinjection needle Animals Drug Administration Routes Drug Delivery Systems Humans Microinjections Needles
Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and hydrogel forming microneedles. In their turn, the modifications have resulted in new mechanisms of drug delivery enhancement and followed by the expansion of applicability range in terms of targeted tissues and organs. Thus, in addition to percutaneous drug delivery, microneedles have been considered as an efficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vaginal drug administration. It is anticipated that the technique of microneedle-assisted drug delivery will soon become relevant for majority of organs and tissues. © 2017 Elsevier B.V.