Lymphocyte subpopulations, levels of interferon, and expression of their receptors in patients with chronic hepatitis B and C: Correlation with the...
Калюжин О. В., Понежева З. Б., Семенова И. В., Хохлова О. Н., Серебровскайа Л. В., Гусева Т. С., Паршина О. В., Малеев В. В.
Терапевтический архив
Т. 89, Вып. 11, С. 14-20
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17116/terarkh2017891114-20
Аннотация:
Aim. To determine whether there is a correlation of the composition of circulating lymphocyte subpopulations, the serum concentrations of interferon (IFN)-α, IFN-γ, and IFN-λ3, and the lymphocyte expression of types I and II IFN receptors with the species of a disease pathogen and the degree of liver fibrosis (LF) in patients with chronic hepatitis B (CHB) and in those with chronic hepatitis C (CHC). Subjects and methods. The investigation enrolled 44 patients with CHC, 9 patients with CHB, and 13 clinically healthy donors. The degree of LF in the patients was determined using transient elastography. The composition of peripheral blood lymphocyte subpopulations was examined; the concentrations of IFN-α, IFN-γ, and IL-28B were estimated. Results. Lymphocyte counts were higher in patients with CHC and in those with CHB than those in healthy donors; and the number of neutrophils was lower. There were no differences between the groups in the composition of lymphocyte subpopulations with th
Ключевые слова:
CD118+ lymphocytes; CD119+ lymphocytes; Hepatitis B; Hepatitis C; Interferon-α; Interferon-γ; Interleukin-28B; Liver fibrosis
interferon; interferon receptor; adult; blood; chronic hepatitis B; chronic hepatitis C; complication; diagnostic imaging; female; human; liver cirrhosis; lymphocyte count; lymphocyte subpopulation; male; middle aged; virology; Adult; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon Type I; Liver Cirrhosis; Lymphocyte Count; Lymphocyte Subsets; Male; Middle Aged; Receptors, Interferon
Язык текста: Русский
ISSN: 2309-5342
Калюжин О. В. Олег Витальевич 1970-
Понежева З. Б. Ж.Б.
Семенова И. В.
Хохлова О. Н.
Серебровскайа Л. В.
Гусева Т. С.
Паршина О. В.
Малеев В. В.
Kalyuzhin O. V. Oleg Vitalyevich 1970-
Ponezheva Z. B. Zh.B.
Semenova I. V.
Khokhlova O. N.
Serebrovskaya L. V.
Guseva T. S.
Parshina O. V.
Maleev V. V.
Lymphocyte subpopulations, levels of interferon, and expression of their receptors in patients with chronic hepatitis B and C: Correlation with the species of viruses and the degree of liver fibrosis
Lymphocyte subpopulations, levels of interferon, and expression of their receptors in patients with chronic hepatitis B and C: Correlation with the...
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 89, Вып. 11 С. 14-20
2017
Статья
CD118+ lymphocytes CD119+ lymphocytes Hepatitis B Hepatitis C Interferon-α Interferon-γ Interleukin-28B Liver fibrosis
interferon interferon receptor adult blood chronic hepatitis B chronic hepatitis C complication diagnostic imaging female human liver cirrhosis lymphocyte count lymphocyte subpopulation male middle aged virology Adult Female Hepatitis B, Chronic Hepatitis C, Chronic Humans Interferon Type I Liver Cirrhosis Lymphocyte Count Lymphocyte Subsets Male Middle Aged Receptors, Interferon
Aim. To determine whether there is a correlation of the composition of circulating lymphocyte subpopulations, the serum concentrations of interferon (IFN)-α, IFN-γ, and IFN-λ3, and the lymphocyte expression of types I and II IFN receptors with the species of a disease pathogen and the degree of liver fibrosis (LF) in patients with chronic hepatitis B (CHB) and in those with chronic hepatitis C (CHC). Subjects and methods. The investigation enrolled 44 patients with CHC, 9 patients with CHB, and 13 clinically healthy donors. The degree of LF in the patients was determined using transient elastography. The composition of peripheral blood lymphocyte subpopulations was examined; the concentrations of IFN-α, IFN-γ, and IL-28B were estimated. Results. Lymphocyte counts were higher in patients with CHC and in those with CHB than those in healthy donors; and the number of neutrophils was lower. There were no differences between the groups in the composition of lymphocyte subpopulations with th