Necrotizing sarcoid granulomatosis with clinical presentations of recurrent acute abdomen. Case report and literature review
Васильев В. И., Палшина С. Г., Чальцев Б. Д., Раденска-Лоповок С. Г., Сафонова Т. Н.
Терапевтический архив
Т. 89, Вып. 11, С. 60-68
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17116/terarkh2017891160-68
Аннотация:
The authors have described the world's first case of necrotizing sarcoid granulomatosis (NSG) in a 22-year-old woman with the clinical presentations of acute abdomen, which are associated with abdominal lymph nodal infiltration and necrosis, obvious constitutional disturbances (fever, nocturnal sweats, and significant weight loss), high inflammatory activity (anemia, leukocytosis, high erythrocyte sedimentation rates and C-reactive protein levels), the gradual appearance of splenic and hepatic necrotic foci, and infiltration into the lung and lacrimal glands with the development of unilateral uveitis. The patient underwent five surgical interventions, several needle biopsies for recurrent abdominal syndrome, and long-term antibiotic treatment for presumed sepsis, which had caused drug-induced hepatitis. Bacteriological examination of blood, puncture samples, and removed abdominal cavity tissues, serological tests, and immunomorphogical study of biopsy samples and removed tissues yielde
Ключевые слова:
Abdominal lymph nodal necrosis; Fludarabine; Granulomatosis with polyangiitis; Granulomatous and lymphocytic vasculitis; Necrotizing sarcoid granulomatosis; Nodular sarcoidosis; Sepsis
acute abdomen; adult; case report; complication; female; human; necrosis; sarcoidosis; Wegener granulomatosis; young adult; Abdomen, Acute; Adult; Female; Granulomatosis with Polyangiitis; Humans; Necrosis; Sarcoidosis; Young Adult
Язык текста: Русский
ISSN: 2309-5342
Васильев В. И.
Палшина С. Г.
Чальцев Б. Д.
Раденска-Лоповок С. Г. Стефка Господинова 1951-
Сафонова Т. Н.
Vasilyev V. I.
Palshina S. G.
Chaltsev B. D.
Radenska-Lopovok S. G. Stefka Gospodinova 1951-
Safonova T. N.
Necrotizing sarcoid granulomatosis with clinical presentations of recurrent acute abdomen. Case report and literature review
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 89, Вып. 11 С. 60-68
2017
Статья
Abdominal lymph nodal necrosis Fludarabine Granulomatosis with polyangiitis Granulomatous and lymphocytic vasculitis Necrotizing sarcoid granulomatosis Nodular sarcoidosis Sepsis
acute abdomen adult case report complication female human necrosis sarcoidosis Wegener granulomatosis young adult Abdomen, Acute Adult Female Granulomatosis with Polyangiitis Humans Necrosis Sarcoidosis Young Adult
The authors have described the world's first case of necrotizing sarcoid granulomatosis (NSG) in a 22-year-old woman with the clinical presentations of acute abdomen, which are associated with abdominal lymph nodal infiltration and necrosis, obvious constitutional disturbances (fever, nocturnal sweats, and significant weight loss), high inflammatory activity (anemia, leukocytosis, high erythrocyte sedimentation rates and C-reactive protein levels), the gradual appearance of splenic and hepatic necrotic foci, and infiltration into the lung and lacrimal glands with the development of unilateral uveitis. The patient underwent five surgical interventions, several needle biopsies for recurrent abdominal syndrome, and long-term antibiotic treatment for presumed sepsis, which had caused drug-induced hepatitis. Bacteriological examination of blood, puncture samples, and removed abdominal cavity tissues, serological tests, and immunomorphogical study of biopsy samples and removed tissues yielde