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Immune response in viral infections of the respiratory tract and rational immunotherapy in children

Колосова Н. Г.
Вопросы практической педиатрии
Т. 12, Вып. 4, С. 63-68
Опубликовано: 2017
Тип ресурса: Статья

DOI:10.20953/1817-7646-2017-4-63-68

Аннотация:
Natural mechanisms of defence against pathogens causing ARVI are divided into congenital and acquired ones, differing in speed and specificity of response. In children who frequently fall ill with viral infections of the respiratory tract, the barrier function of the respiratory epithelium might be decreased and hyperimmune reaction with an excessive inflammatory component can arise. In such cases, immunotherapy should be aimed at recovering the ability to resolve the inflammatory process, changing the direction of the immune system response to the Th1 type. Administration of drugs that simultaneously have antiviral and immunomodulating effects might reduce the excessive T cell activation, promote transition to a new cytokine profile (for instance, from Th2 to Th1 in children with atopy), which optimizes a child's antiviral immunity.
Ключевые слова:
Acute respiratory infections; Immunity; Immunotherapy; Inosine pranobex; Isoprinosine; Paediatrics; Viruses
Язык текста: Русский
ISSN: 2414-9705
Колосова Н. Г.
Kolosova N. G.
Immune response in viral infections of the respiratory tract and rational immunotherapy in children
Текст визуальный непосредственный
Вопросы практической педиатрии
ООО "Издательство "Династия"
Т. 12, Вып. 4 С. 63-68
2017
Статья
Acute respiratory infections Immunity Immunotherapy Inosine pranobex Isoprinosine Paediatrics Viruses
Natural mechanisms of defence against pathogens causing ARVI are divided into congenital and acquired ones, differing in speed and specificity of response. In children who frequently fall ill with viral infections of the respiratory tract, the barrier function of the respiratory epithelium might be decreased and hyperimmune reaction with an excessive inflammatory component can arise. In such cases, immunotherapy should be aimed at recovering the ability to resolve the inflammatory process, changing the direction of the immune system response to the Th1 type. Administration of drugs that simultaneously have antiviral and immunomodulating effects might reduce the excessive T cell activation, promote transition to a new cytokine profile (for instance, from Th2 to Th1 in children with atopy), which optimizes a child's antiviral immunity.