The role of gene polymorphisms of the renin-angiotensin system in the etiology of early and late preeclampsia

The objective. To study the incidence of the angiotensin-converting enzyme ACE gene I/D polymorphism and the angiotensin II type 1 receptor (AGTR1) gene A1166C polymorphism in women, whose pregnancy was complicated by severe early- and late-onset preeclampsia. Patients and methods. A retrospective case-control study was performed that included 41 pregnant women with preeclampsia (basic group) and 25 patients with uncomplicated pregnancy (control group). In the basic group, we singled out two subgroups - early and late preeclampsia. The first (15 patients) comprised cases, when delivery was performed before the 34th weeks of pregnancy due to a severe state of mother and/or fetus. The late preeclampsia group (26 patients) included variants of the development of this complication after the 34th week of gestation. Results. The I/D polymorphism of the angiotensin-converting enzyme ACE gene is associated with a risk for development of PE. The presence of the D-allele enhances the risk of sev