How have our clocks evolved? Adaptive and demographic history of the out-of-African dispersal told by polymorphic loci in circadian genes
Putilov A. A., Dorokhov V. B., Polue`ktov M. G.
Chronobiology International
Vol.35, Issue4, P. 511-532
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1080/07420528.2017.1417314
Аннотация:
The mechanism of the molecular circadian clocks is currently understood as a transcription/translation feedback loop involving more than ten genes. Genetic variation at some of loci in these genes has been shaped by adaptation to environmental factors. In particular, latitudinal clines in allele frequency were documented in several animal species, but the contradictory conclusions were drawn from the results of rare human studies. Here we tested whether the out-of-African dispersal of human populations to higher latitudes of the Eurasian continent was associated with latitude-dependent shifts in allele frequency at polymorphic loci in genes of three (reference, circadian and skin pigmentation) groups. In order to detect the genetics-based signatures left by latitude-driven adaptation and to distinguish them from the confounding effects of population demographic history, we analyzed allele frequencies in 1594 individuals from 5 African and 11 Eurasian populations of the 1000 Genomes Pro
Ключевые слова:
1000 Genomes Project; clock genes; Latitudinal cline; migration out of Africa; morning-evening preference; polygenic selection; skin pigmentation; SNP
circadian rhythm signaling protein; acclimatization; Asian continental ancestry group; biology; Black person; Caucasian; circadian rhythm; gene expression profiling; gene frequency; gene locus; genetic database; genetic polymorphism; genetic selection; genetics; genotype; human; migration; phenotype; skin pigmentation; weather; Acclimatization; African Continental Ancestry Group; Asian Continental Ancestry Group; Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins; Computational Biology; Databases, Genetic; Emigration and Immigration; European Continental Ancestry Group; Gene Expression Profiling; Gene Frequency; Genetic Loci; Genotype; Humans; Phenotype; Polymorphism, Genetic; Selection, Genetic; Skin Pigmentation; Weather
Язык текста: Английский
ISSN: 1525-6073
Putilov A. A.
Dorokhov V. B.
Polue`ktov M. G. Mikhail Guryevich 1969-
Путилов А. А.
Дорохов В. Б.
Полуэктов М. Г. Михаил Гурьевич 1969-
How have our clocks evolved? Adaptive and demographic history of the out-of-African dispersal told by polymorphic loci in circadian genes
Текст визуальный непосредственный
Chronobiology International
Marcel Dekker Inc.
Vol.35, Issue4 P. 511-532
2018
Статья
1000 Genomes Project clock genes Latitudinal cline migration out of Africa morning-evening preference polygenic selection skin pigmentation SNP
circadian rhythm signaling protein acclimatization Asian continental ancestry group biology Black person Caucasian circadian rhythm gene expression profiling gene frequency gene locus genetic database genetic polymorphism genetic selection genetics genotype human migration phenotype skin pigmentation weather Acclimatization African Continental Ancestry Group Asian Continental Ancestry Group Circadian Rhythm Circadian Rhythm Signaling Peptides and Proteins Computational Biology Databases, Genetic Emigration and Immigration European Continental Ancestry Group Gene Expression Profiling Gene Frequency Genetic Loci Genotype Humans Phenotype Polymorphism, Genetic Selection, Genetic Skin Pigmentation Weather
The mechanism of the molecular circadian clocks is currently understood as a transcription/translation feedback loop involving more than ten genes. Genetic variation at some of loci in these genes has been shaped by adaptation to environmental factors. In particular, latitudinal clines in allele frequency were documented in several animal species, but the contradictory conclusions were drawn from the results of rare human studies. Here we tested whether the out-of-African dispersal of human populations to higher latitudes of the Eurasian continent was associated with latitude-dependent shifts in allele frequency at polymorphic loci in genes of three (reference, circadian and skin pigmentation) groups. In order to detect the genetics-based signatures left by latitude-driven adaptation and to distinguish them from the confounding effects of population demographic history, we analyzed allele frequencies in 1594 individuals from 5 African and 11 Eurasian populations of the 1000 Genomes Pro