Diabetes mellitus and male aging: Pharmacotherapeutics and clinical implications
Putta S., Peluso I., Yarla N. S., Kilari E. K., Bishayee A., Lu D. -., Barreto G. E., Ashraf G. M., Scotti L., Scotti M. T., Singla R. K., Alexiou T., Atanasov A. G., Tarasov V. V., Bramhachari P. V., Imandi S. B., Chintala M., Sharma B., Reale M., Filosa R., Aliev G., Kamal M. A.
Current Pharmaceutical Design
Vol.23, Issue30, P. 4475-4483
Опубликовано: 2017
Тип ресурса: Обзор
DOI:10.2174/1381612823666170823103830
Аннотация:
Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years. Older diabetics tend to have both impaired insulin release as well as insulin resistance. There is growing evidence indicating the pathophysiological connections among the mechanisms of oxidative damage by disruption of the oxidative balance, increased levels of enzymatic glycation products in testicular region and glucose transporters, obesity and proinflammatory cytokines in male infertile patients wi
Ключевые слова:
Andropause; Diabetes mellitus; Hypogonadism; Insulin; Proinflammatory cytokines; Testosterone
advanced glycation end product; cytokine; sildenafil; tadalafil; testosterone; testosterone undecanoate; aging; androgen deficiency; androgen therapy; andropause; disease association; ejaculation disorder; erectile dysfunction; human; hypogonadism; inflammation; insulin resistance; libido disorder; male infertility; male sexual dysfunction; non insulin dependent diabetes mellitus; obesity; oxidative stress; pathophysiology; priority journal; Review; testosterone blood level
Язык текста: Английский
ISSN: 1873-4286
Putta S.
Peluso I.
Yarla N. S.
Kilari E. K.
Bishayee A.
Lu D. -. D.-Y.
Barreto G. E.
Ashraf G. M.
Scotti L.
Scotti M. T.
Singla R. K.
Alexiou T.
Atanasov A. G.
Tarasov V. V. Vadim Vladimirovich 1987-
Bramhachari P. V.
Imandi S. B.
Chintala M.
Sharma B.
Reale M.
Filosa R.
Aliev G. Gyumrakh 1958-
Kamal M. A.
Путта С.
Пелусо И.
Ярла Н. С.
Килари Е. К.
Бишайее А.
Лу Д. -. Д.-Y.
Баррето Г. Е.
Ашраф Г. М.
Сcотти Л.
Сcотти М. Т.
Сингла Р. К.
Алехиоу Т.
Атанасов А. Г.
Тарасов В. В. Вадим Владимирович 1987-
Брамхачари П. В.
Иманди С. Б.
Чинтала М.
Шарма Б.
Реале М.
Филоса Р.
Алиев Г. Гюмрах 1958-
Камал М. А.
Diabetes mellitus and male aging: Pharmacotherapeutics and clinical implications
Текст визуальный непосредственный
Current Pharmaceutical Design
Bentham Science Publishers
Vol.23, Issue30 P. 4475-4483
2017
Обзор
Andropause Diabetes mellitus Hypogonadism Insulin Proinflammatory cytokines Testosterone
advanced glycation end product cytokine sildenafil tadalafil testosterone testosterone undecanoate aging androgen deficiency androgen therapy andropause disease association ejaculation disorder erectile dysfunction human hypogonadism inflammation insulin resistance libido disorder male infertility male sexual dysfunction non insulin dependent diabetes mellitus obesity oxidative stress pathophysiology priority journal Review testosterone blood level
Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years. Older diabetics tend to have both impaired insulin release as well as insulin resistance. There is growing evidence indicating the pathophysiological connections among the mechanisms of oxidative damage by disruption of the oxidative balance, increased levels of enzymatic glycation products in testicular region and glucose transporters, obesity and proinflammatory cytokines in male infertile patients wi