Mediastinal teratoma with mature fetal pancreatic tissue, nesidioblastosis and focal hyperplasia of neuroendocrine cells. A case report
Румянцев П. О., Абросимов А. Y., Тертычный А. С., Селиванова Л. С., Слашчук К. Y.
Проблемы эндокринологии
Т. 63, Вып. 5, С. 325-328
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.14341/probl2017635325-328
Аннотация:
We present a clinical case of rare and poorly diagnosable mediastinal teratoma containing elements of mature pancreas tissue, nesidioblastosis, and focal hyperplasia of neuroendocrine cells in a somatically healthy 25-year-old male. The main diagnostic difficulties are associated with the asymptomatic clinical course of mediastinal teratomas that are usually incidentally discovered during X-ray for other conditions. The pathology is characterized by pronounced morphological heterogeneity of the tumor; if the morphologist is not sufficiently qualified, this often results in a false-positive conclusion of neuroendocrine carcinoma, which, in turn, leads to an inadequate amount of treatment and a wrong prognosis in the patient. Therefore, for verification of the diagnosis, histological specimens should be examined by experts of institutions experienced in morphological differential diagnosis. In this case, an immunohistochemical study of the tumor for insulin, cytokeratins, and markers of
Ключевые слова:
Mediastinal teratoma; Nesidioblastosis; Neuroendocrine cells.; Pancreatic tissue
Язык текста: Русский
ISSN: 2308-1430
Румянцев П. О.
Абросимов А. Y.
Тертычный А. С. Александр Семенович 1969-
Селиванова Л. С. Лилия Сергеевна 1989-
Слашчук К. Y.
Rumyantsev P. O.
Abrosimov A. Y.
Terty'chny'j A. S. Aleksandr Semenovich 1969-
Selivanova L. S. Liliya Sergeevna 1989-
Slashchuk K. Y.
Mediastinal teratoma with mature fetal pancreatic tissue, nesidioblastosis and focal hyperplasia of neuroendocrine cells. A case report
Текст визуальный непосредственный
Проблемы эндокринологии
Издательство Медиа Сфера
Т. 63, Вып. 5 С. 325-328
2017
Статья
Mediastinal teratoma Nesidioblastosis Neuroendocrine cells. Pancreatic tissue
We present a clinical case of rare and poorly diagnosable mediastinal teratoma containing elements of mature pancreas tissue, nesidioblastosis, and focal hyperplasia of neuroendocrine cells in a somatically healthy 25-year-old male. The main diagnostic difficulties are associated with the asymptomatic clinical course of mediastinal teratomas that are usually incidentally discovered during X-ray for other conditions. The pathology is characterized by pronounced morphological heterogeneity of the tumor; if the morphologist is not sufficiently qualified, this often results in a false-positive conclusion of neuroendocrine carcinoma, which, in turn, leads to an inadequate amount of treatment and a wrong prognosis in the patient. Therefore, for verification of the diagnosis, histological specimens should be examined by experts of institutions experienced in morphological differential diagnosis. In this case, an immunohistochemical study of the tumor for insulin, cytokeratins, and markers of