Clinical and immunological characteristics of newborn infants from mothers with cancers
Макиева М. И., Матвеева Н. К., Ванко Л. В., Цои Т. А., Жукова А. С., Шаталова Е. А., Полушкина Е. С., Аверянова М. В., Тимофеева Л. А., Кречетова Л. В., Зубков В. В., Шмаков П. Г.
Акушерство и гинекология
Вып. 11, С. 92-99
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.18565/aig.2017.11.92-99
Аннотация:
Objective. To provide the clinical characteristics of the health status and to assess the immune status of neonates born to mothers with cancer who had received chemotherapy during pregnancy. Subjects and methods. Pregnant women with cancer (n = 60) and their newborn infants (n = 64) underwent physical examination. Ultrasonography was used to examine the brain, abdominal organs, kidneys, and heart in all the babies. Flow cytometry was employed to assess the composition of lymphocyte subpopulations in the umbilical cord blood of 27 newborn infants and in the venous blood of their mothers. Results. The babies born to women with cancer had lower weight and height and higher frequency of complications in the early neonatal period, which can be attributed to a lower gestational age due to premature delivery that necessitated a more aggressive therapy in the mother. The signs that stemmed from imbalance in the cellular component of immunity, which were manifested by decreases in the immunore
Ключевые слова:
Chemotherapy; Immunity; Newborn infant; Oncology; Pregnancy
Язык текста: Русский
ISSN: 0300-9092
Макиева М. И.
Матвеева Н. К.
Ванко Л. В.
Цои Т. А.
Жукова А. С.
Шаталова Е. А.
Полушкина Е. С.
Аверянова М. В.
Тимофеева Л. А.
Кречетова Л. В.
Зубков В. В. Виктор Васильевич 1964-
Шмаков П. Г.
Makieva M. I.
Matveeva N. K.
Vanko L. V.
Tsoi T. A.
Zhukova A. S.
Shatalova E. A.
Polushkina E. S.
Averyanova M. V.
Timofeeva L. A.
Krechetova L. V.
Zubkov V. V. Viktor Vasilyevich 1964-
Shmakov P. G.
Clinical and immunological characteristics of newborn infants from mothers with cancers
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Вып. 11 С. 92-99
2017
Статья
Chemotherapy Immunity Newborn infant Oncology Pregnancy
Objective. To provide the clinical characteristics of the health status and to assess the immune status of neonates born to mothers with cancer who had received chemotherapy during pregnancy. Subjects and methods. Pregnant women with cancer (n = 60) and their newborn infants (n = 64) underwent physical examination. Ultrasonography was used to examine the brain, abdominal organs, kidneys, and heart in all the babies. Flow cytometry was employed to assess the composition of lymphocyte subpopulations in the umbilical cord blood of 27 newborn infants and in the venous blood of their mothers. Results. The babies born to women with cancer had lower weight and height and higher frequency of complications in the early neonatal period, which can be attributed to a lower gestational age due to premature delivery that necessitated a more aggressive therapy in the mother. The signs that stemmed from imbalance in the cellular component of immunity, which were manifested by decreases in the immunore