Endometrial glycome in the menstrual cycle and endometrial receptivity

Objective. To carry out a systematic analysis of the data available in the current literature on the cyclicity of endometrial glycomic changes and their impact on receptivity and implantation. Material and methods. The review includes the data of 46 foreign and Russian articles published in the past 22 years and found in the Pubmed database on this topic. Results. Endometrial glycomic changes are described in relation to the phase of the menstrual cycle. The maximum glycomic changes are shown to be observed during the implantation window. The changes in the expression of endometrial epithelium glycans are demonstrated to regulate both positively and negatively implantation. Conclusion. The endometrial glycomic differences established in the proliferative and secretory phases of the cycle suggest that glycans are involved in implantation as determinants of receptivity. The data presented may contribute to increasing knowledge on the pathogenesis of infertility and indicate the need for