Clinical and cost-effectiveness analysis of preimplantation genetic screening in patients of late reproductive age
Долгушина Н. В., Коротченко О. Е., Беик Е. П., Абдурахманова Н. Ф., Илyина Е. О., Кулакова Е. В.
Акушерство и гинекология
Вып. 11, С. 56-61
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.18565/aig.2017.11.56-61
Аннотация:
Objective. To evaluate the clinical cost-effectiveness of preimplantation genetic screening (PGS) in patients of late reproductive age in in vitro fertilization programs (IVF). Subjects and methods. The prospective cohort study included 85 childless couples of late reproductive age, who were divided into groups according to the use of PGS on 3 and 5 days. To search for the least cost-basedand maximally effective (birth of a euploid child) procedure, IVF and IVF/PGS using comparative genomic hybridization (CGH) on day 5 were compared by a decision-making analysis. Results. Odds ratio (OR) for the onset of pregnancy due to PGS by CGH used on day 5 in the group of patients aged 40 years and older was 3.6 (95[%] CI, 0.9; 14.1). OR for live births due to PGS by CGH used on day 5 day in the same group was 4.7 (95[%] CI, 1.1; 19.1). The mean per-live-birth cost of IVF was 754,060 rubles and that of IVF/PGS was 495,797.8 rubles. The per-live-birth cost of treatment by IVF/PGS for infertility was 3
Ключевые слова:
Aneuploidy; Assisted reproductive technologies (ART); Cost-effectiveness analysis; Infertility; Late reproductive age; Preimplantation genetic screening (PGS); Whole-genome hybridization
Язык текста: Русский
ISSN: 0300-9092
Долгушина Н. В. Наталия Витальевна 1972-
Коротченко О. Е. Ольга Евгеньевна 1989-
Беик Е. П.
Абдурахманова Н. Ф. Нигора Фаруховна 1991-
Илyина Е. О.
Кулакова Е. В.
Dolgushina N. V. Nataliya Vitalyevna 1972-
Korotchenko O. E. Ol`ga Evgenyevna 1989-
Beik E. P.
Abdurakhmanova N. F. Nigora Farukhovna 1991-
Ilyina E. O.
Kulakova E. V.
Clinical and cost-effectiveness analysis of preimplantation genetic screening in patients of late reproductive age
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Вып. 11 С. 56-61
2017
Статья
Aneuploidy Assisted reproductive technologies (ART) Cost-effectiveness analysis Infertility Late reproductive age Preimplantation genetic screening (PGS) Whole-genome hybridization
Objective. To evaluate the clinical cost-effectiveness of preimplantation genetic screening (PGS) in patients of late reproductive age in in vitro fertilization programs (IVF). Subjects and methods. The prospective cohort study included 85 childless couples of late reproductive age, who were divided into groups according to the use of PGS on 3 and 5 days. To search for the least cost-basedand maximally effective (birth of a euploid child) procedure, IVF and IVF/PGS using comparative genomic hybridization (CGH) on day 5 were compared by a decision-making analysis. Results. Odds ratio (OR) for the onset of pregnancy due to PGS by CGH used on day 5 in the group of patients aged 40 years and older was 3.6 (95[%] CI, 0.9; 14.1). OR for live births due to PGS by CGH used on day 5 day in the same group was 4.7 (95[%] CI, 1.1; 19.1). The mean per-live-birth cost of IVF was 754,060 rubles and that of IVF/PGS was 495,797.8 rubles. The per-live-birth cost of treatment by IVF/PGS for infertility was 3