A current view on the history of atypical antipsychotics [Sovremennyĭ vzgliad na istoriiu atipichnykh antipsikhoticheskikh sredstv]
Данилов Д. С.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 117, Вып. 5, С. 85-93
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.17116/jnevro20171175185-93
Аннотация:
Based on the analysis of the original literature, the author for the first time systemizes the data on the story of atypical antipsychotic drugs. The history of introduction of the first atypical neuroleptics - clozapine and sulpiride, which launched the dichotomic development of psychopharmacology of atypical antipsychotics, is described. Historical facts on the introduction into practice of different sulpiride- and clozapine-like neuroleptics as well as the relationship of their history with the elaboration of dopamine and serotonin hypotheses of mechanisms of action of antipsychotics are presented. The author analyzes the efficacy and tolerability of treatment with different atypical neuroleptics. An importance of evidence-based medicine principles in the history of atypical antipsychotics is described. A significance of the history of some atypical and typical (pericyazine) neuroleptics in the evolution of conceptions on the validity of evidence-based medicine in psychiatry is eval
Ключевые слова:
5HT2-/D2-antagonists; atypical antipsychotics; benzamide derivatives; clozapine; clozapine-like antipsychotics; D2/D3-antagonists; dopamine theory; evidence-based medicine; history; neurochemical activity; pericyazine; serotonin theory; sulpiride; sulpiride-like antipsychotics; typical antipsychotics
clozapine; neuroleptic agent; periciazine; phenothiazine derivative; sulpiride; history; human; synthesis; Antipsychotic Agents; Clozapine; History, 20th Century; Humans; Phenothiazines; Sulpiride
Язык текста: Русский
ISSN: 2309-4729
Данилов Д. С.
Danilov D. S.
A current view on the history of atypical antipsychotics [Sovremennyĭ vzgliad na istoriiu atipichnykh antipsikhoticheskikh sredstv]
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 117, Вып. 5 С. 85-93
2017
Статья
5HT2-/D2-antagonists atypical antipsychotics benzamide derivatives clozapine clozapine-like antipsychotics D2/D3-antagonists dopamine theory evidence-based medicine history neurochemical activity pericyazine serotonin theory sulpiride sulpiride-like antipsychotics typical antipsychotics
clozapine neuroleptic agent periciazine phenothiazine derivative sulpiride history human synthesis Antipsychotic Agents Clozapine History, 20th Century Humans Phenothiazines Sulpiride
Based on the analysis of the original literature, the author for the first time systemizes the data on the story of atypical antipsychotic drugs. The history of introduction of the first atypical neuroleptics - clozapine and sulpiride, which launched the dichotomic development of psychopharmacology of atypical antipsychotics, is described. Historical facts on the introduction into practice of different sulpiride- and clozapine-like neuroleptics as well as the relationship of their history with the elaboration of dopamine and serotonin hypotheses of mechanisms of action of antipsychotics are presented. The author analyzes the efficacy and tolerability of treatment with different atypical neuroleptics. An importance of evidence-based medicine principles in the history of atypical antipsychotics is described. A significance of the history of some atypical and typical (pericyazine) neuroleptics in the evolution of conceptions on the validity of evidence-based medicine in psychiatry is eval