Prospects for drugs based on the mitochondria-targeting antioxidant SkQ1 in treatment of wounds with impaired healing
Zinovkin R. A., Popova E. N., Pletjushkina O. Y., Ilyinskaya O. P., Pisarev V. M., Chernyak B. V.
Общая реаниматология
Vol.14, Issue2, P. 69-86
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.15360/1813-9779-2018-2-69-86
Аннотация:
Chronic wounds with impared wound healing that require prolong time for healing remain unsolved problem of modern medicine. Excessive oxidative stress plays an important role in the pathogenesis of chronic wounds caused by aging, diabetes and other pathologies. This review is aimed at the role of mitochondria in oxidative stress and to the future prospects for using the innovative mitochondria targeted antioxidants for treatment of impaired wounds. Recent studies in old mice and mice with type 2 diabetes showed that the mitochondrial antioxidant SkQ1 [10- (6'- plastoquinonyl) decyltriphenylphosphonium] stimulates healing of full-thickness dermal wounds. SkQ1 accelerates inflammatory stage of wound healing, maturation of granulation tissue, angiogenesis and epithelization of wounds. The anti-inflammatory effect of SkQ1 is possibly connected to decreased inflammatory activation of the vascular endothelium, which is typical for aging, diabetes and other pathologies. Local administration o
Ключевые слова:
Mitochondria; Reactive oxygen species; Wound healing
Язык текста: Английский
ISSN: 2411-7110
Zinovkin R. A. Roman Alekseevich 1973-
Popova E. N.
Pletjushkina O. Y.
Ilyinskaya O. P.
Pisarev V. M.
Chernyak B. V.
Зиновкин Р. А. Роман Алексеевич 1973-
Попова Е. Н.
Плетйушкина О. Y.
Илyинскайа О. П.
Писарев В. М.
Черняк Б. В.
Prospects for drugs based on the mitochondria-targeting antioxidant SkQ1 in treatment of wounds with impaired healing
Текст визуальный непосредственный
Общая реаниматология
Некоммерческая организация Фонд "Медицина критических состояний"
Vol.14, Issue2 P. 69-86
2018
Статья
Mitochondria Reactive oxygen species Wound healing
Chronic wounds with impared wound healing that require prolong time for healing remain unsolved problem of modern medicine. Excessive oxidative stress plays an important role in the pathogenesis of chronic wounds caused by aging, diabetes and other pathologies. This review is aimed at the role of mitochondria in oxidative stress and to the future prospects for using the innovative mitochondria targeted antioxidants for treatment of impaired wounds. Recent studies in old mice and mice with type 2 diabetes showed that the mitochondrial antioxidant SkQ1 [10- (6'- plastoquinonyl) decyltriphenylphosphonium] stimulates healing of full-thickness dermal wounds. SkQ1 accelerates inflammatory stage of wound healing, maturation of granulation tissue, angiogenesis and epithelization of wounds. The anti-inflammatory effect of SkQ1 is possibly connected to decreased inflammatory activation of the vascular endothelium, which is typical for aging, diabetes and other pathologies. Local administration o