The role of pathogens and innate immune factors in the pathogenesis of urogenital infection in pregnant women
Караулов А. В., Афанас'ев С. С., Алешкин В. А., Бондаренко Н. Л., Воропаева Е. А., Афанасьев М. С., Несвижский Ю. В., Борисова О. Y., Алешкин А. В., Урбан Y. Н., Бочкарева С. С., Борисова А. Б., Воропаев А. Д.
Вопросы гинекологии, акушерства и перинатологии
Т. 17, Вып. 2, С. 77-88
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.20953/1726-1678-2018-2-77-88
Аннотация:
A systematic review substantiates the significance of mutual influence and interaction between infection pathogens, humoral and cell-mediated innate immunity that condition triggering or termination of infectious process, its prodromal period, severity of clinical manifestations and outcomes of urogenital infections in pregnant women. The determining factor is the result of TLRs response to microbial patterns taking into account the preparedness and state of innate immune receptors. The latter might ensure a higher anti-infection resistance to the pathogen up to termination of disease, or to promote the development of infectious process with marked inflammatory reaction, or to make the infectious process chronic up to damaging the tissue cells of the macroorganism. The understanding of the mechanisms of natural anti-infectious resistance and enhanced sensitivity and susceptibility to infectious agents has been objectified. TLRs act as molecular genetic markers of anti-infection resista
Ключевые слова:
Anti-infection resistance; Infection pathogens; Inflammatory reaction; Innate immune factors; TLRs molecular genetic markers of human health
Язык текста: Русский
ISSN: 2414-9152
Караулов А. В. Александр Викторович 1953-
Афанас'ев С. С.
Алешкин В. А.
Бондаренко Н. Л. Наталья Леонидовна 1967-
Воропаева Е. А.
Афанасьев М. С. Максим Станиславович 1978-
Несвижский Ю. В. Юрий Владимирович 1956-
Борисова О. Y. О.Ю.
Алешкин А. В.
Урбан Y. Н. Ю.Н.
Бочкарева С. С.
Борисова А. Б.
Воропаев А. Д.
Karaulov A. V. Aleksandr Viktorovich 1953-
Afanas'ev S. S.
Aleshkin V. A.
Bondarenko N. L. Natal`ya Leonidovna 1967-
Voropaeva E. A.
Afanasyev M. S. Maksim Stanislavovich 1978-
Nesvizhskij Yu. V. Yurij Vladimirovich 1956-
Borisova O. Y. O.Yu.
Aleshkin A. V.
Urban Y. N. Yu.N.
Bochkareva S. S.
Borisova A. B.
Voropaev A. D.
The role of pathogens and innate immune factors in the pathogenesis of urogenital infection in pregnant women
Текст визуальный непосредственный
Вопросы гинекологии, акушерства и перинатологии
ООО "Издательство "Династия"
Т. 17, Вып. 2 С. 77-88
2018
Обзор
Anti-infection resistance Infection pathogens Inflammatory reaction Innate immune factors TLRs molecular genetic markers of human health
A systematic review substantiates the significance of mutual influence and interaction between infection pathogens, humoral and cell-mediated innate immunity that condition triggering or termination of infectious process, its prodromal period, severity of clinical manifestations and outcomes of urogenital infections in pregnant women. The determining factor is the result of TLRs response to microbial patterns taking into account the preparedness and state of innate immune receptors. The latter might ensure a higher anti-infection resistance to the pathogen up to termination of disease, or to promote the development of infectious process with marked inflammatory reaction, or to make the infectious process chronic up to damaging the tissue cells of the macroorganism. The understanding of the mechanisms of natural anti-infectious resistance and enhanced sensitivity and susceptibility to infectious agents has been objectified. TLRs act as molecular genetic markers of anti-infection resista