Serum levels of M-CSF and C-FMS gene polymorphism as predictors of the effectiveness of in vitro fertilization

The objective: To study M-CSF levels in venous blood and CSF1R gene polymorphism in women with tuboperitoneal infertility, who enter an IVF programme, and to assess their prognostic role. Patients and methods: The examination included 120 women, who were divided into two groups: 40 women with effective IVF (group I) and 80 women with ineffective IVF (group II). M-CSF serum levels were determined by ELISA method, the polymorphic marker rs386693509 of the c-fms gene UTR-3 region was examined by PCR method with subsequent Sanger sequencing. Results: Based on OR calculation, prognostically significant concentrations of M-CSF and c-fms genotype were found for diagnosing the development of pregnancy (95[%] CI = [1.934-11.116], p = 0.0021; 95[%] CI = [5.92-37.73], p = 0.0001, respectively). In women with effective IVF, weak correlation was found between M-CSF and the number of oocytes recovered by transvaginal puncture (TVP) (r = 0.3321, p = 0.0363). conclusion. The results of this work confirm a