Аннотация:
Exosomes (vesicles with the size of 30-150 nm) are formed in multivesicular bodies (MVB) by invagination of early endosome membranes and mediate intercellular interactions. Exosomes are secreted by various kinds of cells, their content might be represented by proteins, lipids and nucleic acids, which reflect the functional state of donor cells. The effect of exosomes on recipient cells depends on their quantity and characteristics of their «load». Comparatively recently, placental exosomes secreted by various placental cells have been isolated from blood of pregnant women. A specific protein - placental alkaline phosphatase (PLAP) - has been determined for these exosomes. PLAP-positive exosomes can be found in maternal blood as soon as in the first trimester of pregnancy, their number increases with maturation of the foetus and reaches its maximum by the moment of birth. Although the functional significance of placental exosomes is still investigated, some authors relate changes in the
Руденко Е. Е. Екатерина Евгеньевна 1988-
Трифонова Н. С. Наталья Сяитовна 1979-
Демура Т. А. Татьяна Александровна 1983-
Жарков Н. В. Николай Владимирович 1975-
Коган Е. А. Евгения Алтаровна 1951-
Жукова Е. В. Екатерина Владимировна 1987-
Александров Л. С. Леонид Семенович 1963-
Rudenko E. E. Ekaterina Evgenyevna 1988-
Trifonova N. S. Natal`ya Syaitovna 1979-
Demura T. A. Tat`yana Aleksandrovna 1983-
Zharkov N. V. Nikolay Vladimirovich 1975-
Kogan E. A. Evgeniya Altarovna 1951-
Zhukova E. V. Ekaterina Vladimirovna 1987-
Aleksandrov L. S. Leonid Semenovich 1963-
The role of placental exosomes in the development of pregnancy complications
Текст визуальный непосредственный
Вопросы гинекологии, акушерства и перинатологии
ООО "Издательство "Династия"
Т. 17, Вып. 2 С. 89-96
2018
Обзор
Assisted reproductive technologies Exosomes Immunological tolerance Oocyte donation Placental alkaline phosphatase Pregnancy Pregnancy complications
Exosomes (vesicles with the size of 30-150 nm) are formed in multivesicular bodies (MVB) by invagination of early endosome membranes and mediate intercellular interactions. Exosomes are secreted by various kinds of cells, their content might be represented by proteins, lipids and nucleic acids, which reflect the functional state of donor cells. The effect of exosomes on recipient cells depends on their quantity and characteristics of their «load». Comparatively recently, placental exosomes secreted by various placental cells have been isolated from blood of pregnant women. A specific protein - placental alkaline phosphatase (PLAP) - has been determined for these exosomes. PLAP-positive exosomes can be found in maternal blood as soon as in the first trimester of pregnancy, their number increases with maturation of the foetus and reaches its maximum by the moment of birth. Although the functional significance of placental exosomes is still investigated, some authors relate changes in the