Regulation of lipid peroxidation and ferroptosis in diverse species
Conrad M., Kagan V. E., Bayir H., Pagnussat G. C., Head B., Traber M. G., Stockwell B. R.
Genes and Development
Vol.32, Issue9-10, P. 602-619
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.1101/gad.314674.118
Аннотация:
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis. © 2018 Conrad et al.
Ключевые слова:
Cell death; Ferroptosis; Iron; Lipid peroxidation; ROS; Vitamin E
glutathione; glutathione peroxidase; iron; metal; phospholipid hydroperoxide glutathione peroxidase; antioxidant; reactive oxygen metabolite; adaptation; antioxidant activity; archaeon; bacterium; cell damage; cell death; egg; embryo development; enzyme activity; evidence based medicine; ferroptosis; fungus; genetic analysis; human; in vivo study; invertebrate; lipid peroxidation; mammal; mitochondrion; nonhuman; oocyte development; plant; priority journal; regulatory mechanism; Review; species diversity; vertebrate; yeast; zebra fish; animal; evolution; metabolism; physiology; species difference; Animals; Antioxidants; Biological Evolution; Cell Death; Humans; Iron; Lipid Peroxidation; Reactive Oxygen Species; Species Specificity
Язык текста: Английский
ISSN: 1549-5477
Conrad M.
Kagan V. E. Valerian E 1946-
Bayir H.
Pagnussat G. C.
Head B.
Traber M. G.
Stockwell B. R.
Cонрад М.
Каган В. Е. Валериан Е 1946-
Байир Х.
Пагнуссат Г. C.
Хеад Б.
Трабер М. Г.
Стоcкwелл Б. Р.
Regulation of lipid peroxidation and ferroptosis in diverse species
Текст визуальный непосредственный
Genes and Development
Cold Spring Harbor Laboratory Press
Vol.32, Issue9-10 P. 602-619
2018
Обзор
Cell death Ferroptosis Iron Lipid peroxidation ROS Vitamin E
glutathione glutathione peroxidase iron metal phospholipid hydroperoxide glutathione peroxidase antioxidant reactive oxygen metabolite adaptation antioxidant activity archaeon bacterium cell damage cell death egg embryo development enzyme activity evidence based medicine ferroptosis fungus genetic analysis human in vivo study invertebrate lipid peroxidation mammal mitochondrion nonhuman oocyte development plant priority journal regulatory mechanism Review species diversity vertebrate yeast zebra fish animal evolution metabolism physiology species difference Animals Antioxidants Biological Evolution Cell Death Humans Iron Lipid Peroxidation Reactive Oxygen Species Species Specificity
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis. © 2018 Conrad et al.