Genetic variation in serotonin function impacts on altruistic punishment in the ultimatum game: A longitudinal approach
Gärtner A., Strobel A., Reif A., Lesh K. Yu., Enge S.
Brain and Cognition
Vol.125, P. 37-44
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1016/j.bandc.2018.05.007
Аннотация:
Growing evidence demonstrates that the serotonin system influences punishment behavior in social decision-making and that individual differences in the propensity to punish are, at least in part, due to genetic variation. However, the specific genes and their mechanisms by which they influence punishment behavior are not yet fully characterized. Here, we examined whether serotonin system-related gene variation impacts on altruistic punishment in the ultimatum game by using a longitudinal approach with three time points, covering a time frame up to four months in young adults (N = 106). Specifically, we investigated additive effects of 5-HTTLPR and TPH2 G-703T genotypes by using a composite score. This composite score was significantly associated with altruistic punishment, with individuals carrying both the S-allele and the G-allele demonstrating less punishment behavior. The results suggest that serotonin system-related gene variation contributes to individual differences in altruisti
Ключевые слова:
5-HTTLPR; Altruistic punishment; Social decision-making; Test-retest reliability; TPH2 G-703T; Ultimatum game
serotonin; serotonin transporter; tryptophan hydroxylase 2; serotonin transporter; TPH2 protein, human; tryptophan hydroxylase; adult; allele; Article; controlled study; correlational study; female; genetic polymorphism; genetic stability; genetic variation; genotype; human; human experiment; longitudinal study; male; normal human; priority journal; serotoninergic system; test retest reliability; time perception; university student; young adult; adolescent; altruism; cooperation; decision making; genetics; individuality; punishment; Adolescent; Adult; Alleles; Altruism; Cooperative Behavior; Decision Making; Female; Genetic Variation; Humans; Individuality; Male; Punishment; Serotonin Plasma Membrane Transport Proteins; Tryptophan Hydroxylase; Young Adult
Язык текста: Английский
ISSN: 1090-2147
Gärtner A.
Strobel A.
Reif A.
Lesh K. Yu. Klaus-Peter Yulius 1957-
Enge S.
Гäртнер А.
Стробел А.
Реиф А.
Леш К. Ю. Клаус-Петер Юлиус 1957-
Енге С.
Genetic variation in serotonin function impacts on altruistic punishment in the ultimatum game: A longitudinal approach
Текст визуальный непосредственный
Brain and Cognition
Academic Press
Vol.125 P. 37-44
2018
Статья
5-HTTLPR Altruistic punishment Social decision-making Test-retest reliability TPH2 G-703T Ultimatum game
serotonin serotonin transporter tryptophan hydroxylase 2 serotonin transporter TPH2 protein, human tryptophan hydroxylase adult allele Article controlled study correlational study female genetic polymorphism genetic stability genetic variation genotype human human experiment longitudinal study male normal human priority journal serotoninergic system test retest reliability time perception university student young adult adolescent altruism cooperation decision making genetics individuality punishment Adolescent Adult Alleles Altruism Cooperative Behavior Decision Making Female Genetic Variation Humans Individuality Male Punishment Serotonin Plasma Membrane Transport Proteins Tryptophan Hydroxylase Young Adult
Growing evidence demonstrates that the serotonin system influences punishment behavior in social decision-making and that individual differences in the propensity to punish are, at least in part, due to genetic variation. However, the specific genes and their mechanisms by which they influence punishment behavior are not yet fully characterized. Here, we examined whether serotonin system-related gene variation impacts on altruistic punishment in the ultimatum game by using a longitudinal approach with three time points, covering a time frame up to four months in young adults (N = 106). Specifically, we investigated additive effects of 5-HTTLPR and TPH2 G-703T genotypes by using a composite score. This composite score was significantly associated with altruistic punishment, with individuals carrying both the S-allele and the G-allele demonstrating less punishment behavior. The results suggest that serotonin system-related gene variation contributes to individual differences in altruisti