Limitation of biocompatibility of hydrated nanocrystalline hydroxyapatite
Minaychev V. V., Teleshev A. T., Gorshenev V. N., Yakovleva M. A., Fomichev V. A., Pankratov A. S., Menshikh K. A., Fadeev R. S., Fadeeva I. S., Senotov A. S., Kobyakova M. I., Yurasova Y. B., Akatov V. S.
IOP Conference Series: Materials Science and Engineering
Vol.347, Issue1, Num.012045
Опубликовано: 2018
Тип ресурса: Материалы конференции (Статья)
DOI:10.1088/1757-899X/347/1/012045
Аннотация:
Nanostructured hydroxyapatite (HA) in the form of hydrated paste is considered to be a promising material for a minor-invasive surgical curing of bone tissue injure. However questions about adhesion of cells on this material and its biocompatibility still remain. In this study biocompatibility of paste-formed nanosized HA (nano-HA) by in vitro methods is investigated. Nano-HA (particles sized about 20 nm) was synthesized under conditions of mechano-acoustic activation of an aqueous reaction mixture of ammonium hydrophosphate and calcium nitrate. It was ascertained that nanocrystalline paste was not cytotoxic although limitation of adhesion, spreading and growth of the cells on its surface was revealed. The results obtained point on the need of modification of hydrated nano-HA in the aims of increasing its biocompatibility and osteoplastic potential. © 2018 Institute of Physics Publishing. All rights reserved.
Ключевые слова:
Adhesion; Biocompatibility; Calcium compounds; Hydration; Hydroxyapatite; Aqueous reaction mixtures; Bone tissue; Calcium nitrate; Cytotoxic; Hydrophosphate; In-vitro; Nanocrystallines; Nanostructured hydroxyapatite; Nanocrystals
Язык текста: Английский
ISSN: 1757-899X
Minaychev V. V.
Teleshev A. T.
Gorshenev V. N.
Yakovleva M. A.
Fomichev V. A.
Pankratov A. S. Aleksandr Sergeevich 1963-
Menshikh K. A.
Fadeev R. S.
Fadeeva I. S.
Senotov A. S.
Kobyakova M. I.
Yurasova Y. B.
Akatov V. S.
Минайчев В. В.
Телешев А. Т.
Горшенев В. Н.
Яковлева М. А.
Фомичев В. А.
Панкратов А. С. Александр Сергеевич 1963-
Менших К. А.
Фадеев Р. С.
Фадеева И. С.
Сенотов А. С.
Кобякова М. И.
Юрасова Y. Б.
Акатов В. С.
Limitation of biocompatibility of hydrated nanocrystalline hydroxyapatite
Текст визуальный непосредственный
IOP Conference Series: Materials Science and Engineering
Vol.347, Issue1 Num.012045
2018
Материалы конференции (Статья)
Adhesion Biocompatibility Calcium compounds Hydration Hydroxyapatite Aqueous reaction mixtures Bone tissue Calcium nitrate Cytotoxic Hydrophosphate In-vitro Nanocrystallines Nanostructured hydroxyapatite Nanocrystals
Nanostructured hydroxyapatite (HA) in the form of hydrated paste is considered to be a promising material for a minor-invasive surgical curing of bone tissue injure. However questions about adhesion of cells on this material and its biocompatibility still remain. In this study biocompatibility of paste-formed nanosized HA (nano-HA) by in vitro methods is investigated. Nano-HA (particles sized about 20 nm) was synthesized under conditions of mechano-acoustic activation of an aqueous reaction mixture of ammonium hydrophosphate and calcium nitrate. It was ascertained that nanocrystalline paste was not cytotoxic although limitation of adhesion, spreading and growth of the cells on its surface was revealed. The results obtained point on the need of modification of hydrated nano-HA in the aims of increasing its biocompatibility and osteoplastic potential. © 2018 Institute of Physics Publishing. All rights reserved.