Graefe's Archive for Clinical and Experimental Ophthalmology
Vol.256, Issue9, P. 1751-1756
Аннотация:
Purpose: The aim of this study was to distinguish different forms of orbital involvement in granulomatosis with polyangiitis (GPA) and to compare their clinical course and outcomes. Methods: Two hundred twenty-six consecutive patients with GPA were retrospectively studied. All patients fulfilled the classification criteria of American College of Rheumatology; diagnosis of localized GPA was established according to Chapel Hill Consensus. Of those, 74 patients with orbital disease were enrolled into further investigation of different forms of orbital disease. Results: Overall ocular involvement was diagnosed in 50[%] (113/226) of patients; in 5.3[%] (12/226), inflammatory eye disease resulted in permanent visual loss. Most common ophthalmic manifestations were orbital masses, episcleritis/conjunctivitis, and scleritis (74/226, 32/226, and 12/226, respectively). Seventy-four patients with orbital involvement were divided into three groups: those with orbital mass without primary lacrimal glan
Ключевые слова:
Dacryoadenitis; Granulomatosis with polyangiitis; Myositis; Ophthalmic manifestations; Orbital mass
azathioprine; cyclophosphamide; cytostatic agent; glucocorticoid; methotrexate; rituximab; adolescent; adult; aged; Article; best corrected visual acuity; clinical feature; clinical outcome; conjunctivitis; dacryocystitis; diplopia; disease course; episcleritis; eye enucleation; eye movement disorder; female; human; immunosuppressive treatment; inflammatory disease; keratitis; lacrimal gland disease; major clinical study; male; medical record review; myositis; orbit disease; peripheral ulcerative keratitis; priority journal; retrospective study; scleritis; strabismus; visual impairment; Wegener granulomatosis; complication; diagnostic imaging; follow up; middle aged; orbit; orbit disease; very elderly; Wegener granulomatosis; x-ray computed tomography; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Granulomatosis with Polyangiitis; Humans; Male; Middle Aged; Orbit; Orbital Diseases; Retrospective Studies; Tomography, X-Ray Computed; Young Adult
Ismailova D. S. Dilyara Sultanmuratovna 1981-
Abramova J. V.
Novikov P. I. Pavel Igorevich 1982-
Grusha Ya. O. Yaroslav Olegovich 1968-
Исмаилова Д. С. Диляра Султанмуратовна 1981-
Абрамова Й. В.
Новиков П. И. Павел Игоревич 1982-
Груша Я. О. Ярослав Олегович 1968-
Clinical features of different orbital manifestations of granulomatosis with polyangiitis
Текст визуальный непосредственный
Graefe's Archive for Clinical and Experimental Ophthalmology
Springer-Verlag GmbH
Vol.256, Issue9 P. 1751-1756
2018
Статья
Dacryoadenitis Granulomatosis with polyangiitis Myositis Ophthalmic manifestations Orbital mass
azathioprine cyclophosphamide cytostatic agent glucocorticoid methotrexate rituximab adolescent adult aged Article best corrected visual acuity clinical feature clinical outcome conjunctivitis dacryocystitis diplopia disease course episcleritis eye enucleation eye movement disorder female human immunosuppressive treatment inflammatory disease keratitis lacrimal gland disease major clinical study male medical record review myositis orbit disease peripheral ulcerative keratitis priority journal retrospective study scleritis strabismus visual impairment Wegener granulomatosis complication diagnostic imaging follow up middle aged orbit orbit disease very elderly Wegener granulomatosis x-ray computed tomography young adult Adolescent Adult Aged Aged, 80 and over Female Follow-Up Studies Granulomatosis with Polyangiitis Humans Male Middle Aged Orbit Orbital Diseases Retrospective Studies Tomography, X-Ray Computed Young Adult
Purpose: The aim of this study was to distinguish different forms of orbital involvement in granulomatosis with polyangiitis (GPA) and to compare their clinical course and outcomes. Methods: Two hundred twenty-six consecutive patients with GPA were retrospectively studied. All patients fulfilled the classification criteria of American College of Rheumatology; diagnosis of localized GPA was established according to Chapel Hill Consensus. Of those, 74 patients with orbital disease were enrolled into further investigation of different forms of orbital disease. Results: Overall ocular involvement was diagnosed in 50[%] (113/226) of patients; in 5.3[%] (12/226), inflammatory eye disease resulted in permanent visual loss. Most common ophthalmic manifestations were orbital masses, episcleritis/conjunctivitis, and scleritis (74/226, 32/226, and 12/226, respectively). Seventy-four patients with orbital involvement were divided into three groups: those with orbital mass without primary lacrimal glan