Obesity and functional state of kidney depends on VEGF polymorphism
Shulkina S. G., Smirnova E. N., Osadchuk M. A., Trushin M. V.
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue5, P. 1259-1262
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
The aim this study was to investigate the relationship of polymorphism VEGF gene to the functional state of kidneys in patients with various phenotypes of obesity. We examined 240 persons (mean age of 43.4±7.3), which were distributed in several groups. The first group included 90 patients with obesity with metabolic disorders. The second group was presented by 50 patients-they do not display signs of metabolic disorder. The control group was composed of healthy. We detected high levels of VEGF in blood and urine, A2, type IV collagen and predominance of minor C allele in group 1. In group 2, there were VEGF increase in blood and urine (at optimal values of GFR and A1). We detected a link between polymorphism of promoter region of-634 G/С with levels of SBP, GFR, A2, type IV collagen and increased expression of VEGF in blood and urine. The increase in VEGF in the urine reflects the activation of angiogenesis and endothelial dysfunction, aggravated during the development and progression
Ключевые слова:
Gene; Kidney; Metabolic disorder; Obesity; Polymorphism; VEGF
biological marker; collagen type 4; vasculotropin; very low density lipoprotein cholesterol; abnormal blood pressure; adult; albuminuria; angiogenesis; Article; body mass; chronic kidney failure; controlled study; endothelial dysfunction; enzyme linked immunosorbent assay; female; gene; genetic polymorphism; glomerulus filtration rate; glucose blood level; high density lipoprotein cholesterol level; human; hypertension; kidney function; major clinical study; male; metabolic disorder; obesity; single nucleotide polymorphism; triacylglycerol blood level; urinalysis; VEGF gene
Язык текста: Английский
ISSN: 0975-1459
Shulkina S. G.
Smirnova E. N.
Osadchuk M. A. Mikhail Alekseevich 1951-
Trushin M. V.
Шулкина С. Г.
Смирнова Е. Н.
Осадчук М. А. Михаил Алексеевич 1951-
Трушин М. В.
Obesity and functional state of kidney depends on VEGF polymorphism
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue5 P. 1259-1262
2018
Статья
Gene Kidney Metabolic disorder Obesity Polymorphism VEGF
biological marker collagen type 4 vasculotropin very low density lipoprotein cholesterol abnormal blood pressure adult albuminuria angiogenesis Article body mass chronic kidney failure controlled study endothelial dysfunction enzyme linked immunosorbent assay female gene genetic polymorphism glomerulus filtration rate glucose blood level high density lipoprotein cholesterol level human hypertension kidney function major clinical study male metabolic disorder obesity single nucleotide polymorphism triacylglycerol blood level urinalysis VEGF gene
The aim this study was to investigate the relationship of polymorphism VEGF gene to the functional state of kidneys in patients with various phenotypes of obesity. We examined 240 persons (mean age of 43.4±7.3), which were distributed in several groups. The first group included 90 patients with obesity with metabolic disorders. The second group was presented by 50 patients-they do not display signs of metabolic disorder. The control group was composed of healthy. We detected high levels of VEGF in blood and urine, A2, type IV collagen and predominance of minor C allele in group 1. In group 2, there were VEGF increase in blood and urine (at optimal values of GFR and A1). We detected a link between polymorphism of promoter region of-634 G/С with levels of SBP, GFR, A2, type IV collagen and increased expression of VEGF in blood and urine. The increase in VEGF in the urine reflects the activation of angiogenesis and endothelial dysfunction, aggravated during the development and progression