Journal of Pharmaceutical Sciences and Research
Vol.10, Issue5, P. 1272-1276
Аннотация:
At present, there is a strong need for the unbiased methods for the assessment of the quality of aqueous extracts obtained from various herbal materials. Due to the lack of methods, the quality of such preparations can be assured primarily by quality assessment of the starting material. Current pharmacopoeial monographs on herbal material include mandatory “Content” section, which was absent in the earlier editions of the State Pharmacopoeia of the Russian Federation. The section prescribes assay of biologically active compounds in the aqueous extract, which can be performed in several ways: by qualitative assessment of a single compound, several compounds, or by assessment of total content of a group of compounds expressed as a single reference compound. The choice of target compound for the assay is stipulated by its extractability and pharmacological (therapeutic) activity. Assay is usually performed using modern instrumental methods, e.g., spectrophotometry, chromatography, etc. Ho
Ключевые слова:
Biologically active compounds; Herbal drugs; Herbal mixtures; Standardization
coumarin; essential oil; flavonoid; Glycyrrhiza glabra extract; glycyrrhizic acid; herbaceous agent; Humulus lupulus extract; luteolin; Melilotus extract; peppermint; rutoside; sedative agent; tannin; valerian; Article; diagnostic procedure; drug mixture; linearity; measurement accuracy; measurement repeatability; oregano; particle size; quality control; spectrophotometry; standardization; validation study
Trifonova O. B. Ol`ga Bronislavovna 1975-
Evdokimova O. V. Ol`ga Vladimirovna 1967-
Prokofyeva V. I. Vera Ivanovna 1945-
Matushin A. A. Aleksej Arkadyevich 1984-
Sakanyan E. I.
Трифонова О. Б. Ольга Брониславовна 1975-
Евдокимова О. В. Ольга Владимировна 1967-
Прокофьева В. И. Вера Ивановна 1945-
Матюшин А. А. Алексей Аркадьевич 1984-
Саканян Е. И.
Development of a methodology for standardization of herbal drug mixtures
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue5 P. 1272-1276
2018
Статья
Biologically active compounds Herbal drugs Herbal mixtures Standardization
coumarin essential oil flavonoid Glycyrrhiza glabra extract glycyrrhizic acid herbaceous agent Humulus lupulus extract luteolin Melilotus extract peppermint rutoside sedative agent tannin valerian Article diagnostic procedure drug mixture linearity measurement accuracy measurement repeatability oregano particle size quality control spectrophotometry standardization validation study
At present, there is a strong need for the unbiased methods for the assessment of the quality of aqueous extracts obtained from various herbal materials. Due to the lack of methods, the quality of such preparations can be assured primarily by quality assessment of the starting material. Current pharmacopoeial monographs on herbal material include mandatory “Content” section, which was absent in the earlier editions of the State Pharmacopoeia of the Russian Federation. The section prescribes assay of biologically active compounds in the aqueous extract, which can be performed in several ways: by qualitative assessment of a single compound, several compounds, or by assessment of total content of a group of compounds expressed as a single reference compound. The choice of target compound for the assay is stipulated by its extractability and pharmacological (therapeutic) activity. Assay is usually performed using modern instrumental methods, e.g., spectrophotometry, chromatography, etc. Ho