Sleep disorders associated with Alzheimer's disease: A perspective
Brzecka A., Leszek J., Ashraf G. M., Ejma M., Ávila-Rodriguez M. F., Yarla N. S., Tarasov V. V., Chubarev V. N., Samsonova A. N., Barreto G. E., Aliev G.
Frontiers in Neuroscience
Vol.12, IssueMAY, Num.330
Опубликовано: 2018
Тип ресурса: Краткий обзор
DOI:10.3389/fnins.2018.00330
Аннотация:
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid
Ключевые слова:
AD; Diagnosis; Disturbance; Sleep disorders; Sleep-rhythm
amyloid beta protein; actimetry; Alzheimer disease; brain interstitial fluid; circadian rhythm sleep disorder; clinical feature; cognitive defect; degenerative disease; disease association; human; neurophysiology; polysomnography; prognosis; questionnaire; REM sleep; restless legs syndrome; Short Survey; sleep deprivation; sleep disorder; sleep disordered breathing; sleep pattern; sleep time; sleep waking cycle
Язык текста: Английский
ISSN: 1662-453X
Brzecka A.
Leszek J.
Ashraf G. M.
Ejma M.
Ávila-Rodriguez M. F.
Yarla N. S.
Tarasov V. V. Vadim Vladimirovich 1987-
Chubarev V. N. Vladimir Nikolaevich 1954-
Samsonova A. N.
Barreto G. E.
Aliev G. Gyumrakh 1958-
Брзеcка А.
Лесзек Й.
Ашраф Г. М.
Ейма М.
Áвила-Родригуез М. Ф.
Ярла Н. С.
Тарасов В. В. Вадим Владимирович 1987-
Чубарев В. Н. Владимир Николаевич 1954-
Самсонова А. Н.
Баррето Г. Е.
Алиев Г. Гюмрах 1958-
Sleep disorders associated with Alzheimer's disease: A perspective
Текст визуальный непосредственный
Frontiers in Neuroscience
Frontiers Research Foundation
Vol.12, IssueMAY Num.330
2018
Краткий обзор
AD Diagnosis Disturbance Sleep disorders Sleep-rhythm
amyloid beta protein actimetry Alzheimer disease brain interstitial fluid circadian rhythm sleep disorder clinical feature cognitive defect degenerative disease disease association human neurophysiology polysomnography prognosis questionnaire REM sleep restless legs syndrome Short Survey sleep deprivation sleep disorder sleep disordered breathing sleep pattern sleep time sleep waking cycle
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid