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The role of extracellular fetal dna in predicting the great obstetric syndromes

Карапетян А. О., Баева М. О., Баев О. Р.
Акушерство и гинекология
Вып. 4, С. 10-15
Опубликовано: 2018
Тип ресурса: Статья

DOI:10.18565/aig.2018.4.10-15

Аннотация:
Objective. To present an analysis of the data available in the literature on the role of extracellular fetal DNA (fDNA) in predicting the great obstetric syndromes. Material and methods. Literature sources published in databases, such as Pubmed and Scopus, were sought. Results. There is evidence indicating that increased maternal blood DNA levels can be used as a predictive marker for pregnancy complications, such as preeclampsia, preterm birth, and fetal growth retardation. The most likely mechanism for increasing maternal blood fDNA is the strengthening of apoptotic, necrotic, and inflammatory processes in the placenta. However, not all studies confirm that there is a relationship between the development of the great obstetric syndromes and higher fDNA concentrations. Conceivably, the contradictions are due to the use of a number of procedures to determine fDNA, which limit sampling by sex and rhesus factor. Also, there is no consensus on the time when its concentration starts to inc
Ключевые слова:
Extracellular fetal DNA; Fetal growth retardation; Preeclampsia; Preterm birth
Язык текста: Русский
ISSN: 0300-9092
Карапетян А. О.
Баева М. О. Мадина Олеговна 1986-
Баев О. Р. Олег Радомирович 1957-
Karapetyan A. O.
Baeva M. O. Madina Olegovna 1986-
Baev O. R. Oleg Radomirovich 1957-
The role of extracellular fetal dna in predicting the great obstetric syndromes
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Вып. 4 С. 10-15
2018
Статья
Extracellular fetal DNA Fetal growth retardation Preeclampsia Preterm birth
Objective. To present an analysis of the data available in the literature on the role of extracellular fetal DNA (fDNA) in predicting the great obstetric syndromes. Material and methods. Literature sources published in databases, such as Pubmed and Scopus, were sought. Results. There is evidence indicating that increased maternal blood DNA levels can be used as a predictive marker for pregnancy complications, such as preeclampsia, preterm birth, and fetal growth retardation. The most likely mechanism for increasing maternal blood fDNA is the strengthening of apoptotic, necrotic, and inflammatory processes in the placenta. However, not all studies confirm that there is a relationship between the development of the great obstetric syndromes and higher fDNA concentrations. Conceivably, the contradictions are due to the use of a number of procedures to determine fDNA, which limit sampling by sex and rhesus factor. Also, there is no consensus on the time when its concentration starts to inc