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The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DLhomocysteine thiolactone on serum biochemical parameters, plasma...

Kornjača D., Živković V., Krstić D., Čolović M., Durić M., Stanković S., Mutavdžin S., Jakovljeví V., Durí D.
Archives of Biological Sciences
Vol.70, Issue2, P. 241-248
Опубликовано: 2018
Тип ресурса: Статья

DOI:10.2298/ABS170731041K

Аннотация:
The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9[%] NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLH
Ключевые слова:
acetylcholinesterase; Antioxidant enzymes; DL-homocysteine; DL-homocysteine thiolactone; Rat
Язык текста: Английский
ISSN: 1821-4339
Kornjača D.
Živković V.
Krstić D.
Čolović M.
Durić M.
Stanković S.
Mutavdžin S.
Jakovljeví V.
Durí D.
Корнйаčа Д.
Žивковиć В.
Крстиć Д.
Čоловиć М.
Дуриć М.
Станковиć С.
Мутавдžин С.
Йаковлйевí В.
Дурí Д.
The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DLhomocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat
The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DLhomocysteine thiolactone on serum biochemical parameters, plasma...
Текст визуальный непосредственный
Archives of Biological Sciences
Institut za Bioloska Istrazivanja "Sinisa Stankovic"
Vol.70, Issue2 P. 241-248
2018
Статья
acetylcholinesterase Antioxidant enzymes DL-homocysteine DL-homocysteine thiolactone Rat
The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9[%] NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLH