Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C
Smirnov V. V., Krasnykh L. M., Shilovskii I. P., Ry'zhenkova A. P., Khaitov M. R., Drozdov V. N.
Pharmaceutical Chemistry Journal
Vol.52, Issue3, P. 254-256
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s11094-018-1802-9
Аннотация:
The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
hepatitis C; HPLC-UV; liposomes; RNA interference; spectrophotometry
lipopeptide; liposome; small interfering RNA; analytic method; Article; chromatography; drug analysis; drug formulation; hepatitis C; high performance liquid chromatography; retention time; RNA interference; ultraviolet spectrophotometry; ultraviolet spectroscopy; virus replication
Язык текста: Английский
ISSN: 1573-9031
Smirnov V. V. Valerij Valeryevich 1985-
Krasnykh L. M.
Shilovskii I. P.
Ry'zhenkova A. P. Aleksandra Petrovna 1946-
Khaitov M. R.
Drozdov V. N. Vladimir Nikolaevich 1963-
Смирнов В. В. Валерий Валерьевич 1985-
Краснyх Л. М.
Шиловскии И. П.
Рыженкова А. П. Александра Петровна 1946-
Хаитов М. Р.
Дроздов В. Н. Владимир Николаевич 1963-
Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.52, Issue3 P. 254-256
2018
Статья
hepatitis C HPLC-UV liposomes RNA interference spectrophotometry
lipopeptide liposome small interfering RNA analytic method Article chromatography drug analysis drug formulation hepatitis C high performance liquid chromatography retention time RNA interference ultraviolet spectrophotometry ultraviolet spectroscopy virus replication
The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.