Аннотация:
Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Krasnyuk I. I. Ivan Ivanovich 1955-
Kosheleva T. M. Tat`yana Mikhaylovna 1992-
Belyatskaya A. V. Anastasiya Vladimirovna 1982-
Krasnyuk I. I. Ivan Ivanovich 1955-
Stepanova O. I. Ol`ga Ivanovna 1988-
Skovpen Y.
Grikh V. V. Viktoriya Vladimirovna 1990-
Ovsyannikova L. V. Lyubov` Vitalyevna 1989-
Краснюк И. И. Иван Иванович 1955-
Кошелева Т. М. Татьяна Михайловна 1992-
Беляцкая А. В. Анастасия Владимировна 1982-
Краснюк И. И. Иван Иванович 1955-
Степанова О. И. Ольга Ивановна 1988-
Сковпен Y.
Грих В. В. Виктория Владимировна 1990-
Овсянникова Л. В. Любовь Витальевна 1989-
Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.52, Issue3 P. 241-244
2018
Статья
crystallinity indomethacin polyethylene glycol 1500 solid dispersions solubility
indometacin macrogol Article colloid concentration ratio crystal structure dispersion dissolution drug absorption drug solubility optical density physical chemistry solid dispersion surface property ultraviolet spectrophotometry
Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.