Differences between α-linolenic and linoleic acid supplementation on the redox status and cardiodynamic parameters of male and female Wistar albino...
Radoman K., Živković V., Nikolić T., Stojić I., Raičević D., Jeremić J., Srejović I., Yakovlevich V.
Archives of Biological Sciences
Vol.70, Issue2, P. 223-231
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.2298/ABS170810038R
Аннотация:
The aim of present study was to investigate the difference between α-linolenic acid (ALA, omega-3) and linoleic acid (LA, n-6) on the redox status and cardiac function of the isolated rat heart. ALA or LA were administered for 6 weeks by gavage to all animals, which were randomly divided into 4 groups: male rats treated with a linoleic acid (M-LA), dose of 7.3 mg/kg/day; female rats treated with a linoleic acid (F-LA), dose of 7.3 mg/kg/day; male rats treated with an α-linolenic acid (M-ALA), dose of 165 mg/kg/day; female rats treated with α-linolenic acid (F-ALA), dose of 165 mg/kg/day. Using the Langendorff technique, markers of heart function were evaluated: the maximum and minimum rates of pressure development in the left ventricle (LV; dp/dt max, dp/dt min), systolic and diastolic left ventricle pressure (SLVP, DLVP, respectively), heart rate (HR) and coronary flow (CF). We measured the concentrations of prooxidative markers: nitrites (NO2 -), superoxide anion radicals (O2 -) and
Ключевые слова:
Cardiac contractility; Linoleic acid; Rat; Redox status; α-linolenic acid
Язык текста: Английский
ISSN: 1821-4339
Radoman K.
Živković V.
Nikolić T.
Stojić I.
Raičević D.
Jeremić J.
Srejović I.
Yakovlevich V. Vladimir 1971-
Радоман К.
Žивковиć В.
Николиć Т.
Стойиć И.
Раиčевиć Д.
Йеремиć Й.
Срейовиć И.
Яковлевич В. Владимир 1971-
Differences between α-linolenic and linoleic acid supplementation on the redox status and cardiodynamic parameters of male and female Wistar albino rats
Differences between α-linolenic and linoleic acid supplementation on the redox status and cardiodynamic parameters of male and female Wistar albino...
Текст визуальный непосредственный
Archives of Biological Sciences
Institut za Bioloska Istrazivanja "Sinisa Stankovic"
Vol.70, Issue2 P. 223-231
2018
Статья
Cardiac contractility Linoleic acid Rat Redox status α-linolenic acid
The aim of present study was to investigate the difference between α-linolenic acid (ALA, omega-3) and linoleic acid (LA, n-6) on the redox status and cardiac function of the isolated rat heart. ALA or LA were administered for 6 weeks by gavage to all animals, which were randomly divided into 4 groups: male rats treated with a linoleic acid (M-LA), dose of 7.3 mg/kg/day; female rats treated with a linoleic acid (F-LA), dose of 7.3 mg/kg/day; male rats treated with an α-linolenic acid (M-ALA), dose of 165 mg/kg/day; female rats treated with α-linolenic acid (F-ALA), dose of 165 mg/kg/day. Using the Langendorff technique, markers of heart function were evaluated: the maximum and minimum rates of pressure development in the left ventricle (LV; dp/dt max, dp/dt min), systolic and diastolic left ventricle pressure (SLVP, DLVP, respectively), heart rate (HR) and coronary flow (CF). We measured the concentrations of prooxidative markers: nitrites (NO2 -), superoxide anion radicals (O2 -) and