Pharmaceutical Chemistry Journal
Vol.52, Issue3, P. 195-197
Аннотация:
Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve (AUC) and maximum concentration (Cmax) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
calcium; calcium-creatinine coefficient; clinical trials in vivo; comparative pharmacokinetics; endogenous compounds; parathormone
calcium derivative; colecalciferol; creatinine; parathyroid hormone; adult; area under the curve; Article; bioequivalence; calcium excretion; calcium homeostasis; clinical article; comparative study; creatinine clearance; creatinine urine level; drug bioavailability; human; male; maximum concentration; normal human; pharmacokinetic parameters; plasma concentration-time curve; urinary excretion
Eremenko N. N. Natal`ya Nikolaevna 1979-
Shikh E. V. Evgeniya Valeryevna 1962-
Serebrova S. Yu. Svetlana Yuryevna 1971-
Goryachev D. V.
Еременко Н. Н. Наталья Николаевна 1979-
Ших Е. В. Евгения Валерьевна 1962-
Сереброва С. Ю. Светлана Юрьевна 1971-
Горячев Д. В.
Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.52, Issue3 P. 195-197
2018
Статья
calcium calcium-creatinine coefficient clinical trials in vivo comparative pharmacokinetics endogenous compounds parathormone
calcium derivative colecalciferol creatinine parathyroid hormone adult area under the curve Article bioequivalence calcium excretion calcium homeostasis clinical article comparative study creatinine clearance creatinine urine level drug bioavailability human male maximum concentration normal human pharmacokinetic parameters plasma concentration-time curve urinary excretion
Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve (AUC) and maximum concentration (Cmax) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.