Arbidol: A quarter-century after. Past, present and future of the original Russian antiviral
Balakin K. V., Filosa R., Lavrenov S. N., Mkrtchyan A. S., Nawrozkij M. B., Novakov I. A.
Russian Chemical Reviews
Vol.87, Issue6, P. 509-552
Опубликовано: 2018
Тип ресурса: Обзор
Аннотация:
The present review is concerned with the synthesis and structure-activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed. © 2018 Uspekhi Khimii, Russian Academy of Sciences and Turpion Ltd.
Язык текста: Английский
ISSN: 1468-4837
Balakin K. V. Konstantin Valeryevich 1970-
Filosa R.
Lavrenov S. N.
Mkrtchyan A. S.
Nawrozkij M. B.
Novakov I. A.
Балакин К. В. Константин Валерьевич 1970-
Филоса Р.
Лавренов С. Н.
Мкртчян А. С.
Наwрозкий М. Б.
Новаков И. А.
Arbidol: A quarter-century after. Past, present and future of the original Russian antiviral
Текст визуальный непосредственный
Russian Chemical Reviews
Turpion Limited
Vol.87, Issue6 P. 509-552
2018
Обзор
The present review is concerned with the synthesis and structure-activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed. © 2018 Uspekhi Khimii, Russian Academy of Sciences and Turpion Ltd.