Аннотация:
The liposomal form of silibinin was obtained, and its antihepatotoxic activity in mice was studied using a model of acute toxic hepatitis caused by injection of carbon tetrachloride or paracetamol. It was shown that the use of the drug in therapy or prevention regimens leads to normalization of levels of transaminases and total protein in the blood of experimental animals. The results of the study showed that liposomal silibinin when administered intravenously shows a more pronounced hepatoprotective effect compared to intragastric administration of free silibinin. Thus, the effectiveness of the therapeutic action of silibinin can be significantly increased by using its liposomal form. Liposomal drug, in contrast to native silibinin, can be injected directly into the blood that significantly increases its bioavailability. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
Drug delivery systems; Hepatitis; Liposomes; Silibinin
Biochemistry; Blood; Drug products; Flavonoids; Liposomes; Antihepatotoxic activity; Drug delivery system; Experimental animals; Hepatitis; Hepatoprotective effects; Intragastric administration; Silibinin; Toxic hepatitis; Drug delivery; alanine aminotransferase; aspartate aminotransferase; carbon tetrachloride; cholesterol; cytochrome P450; liposome; liver protective agent; paracetamol; phosphatidylcholine; silibinin; animal experiment; animal model; Article; comparative study; controlled study; drug efficacy; high performance liquid chromatography; liposomal delivery; liver protection; mouse; nonhuman; particle size; scanning electron microscopy; toxic hepatitis
Lutsenko S. V. Sergej Viktorovich 1957-
Gromovy'kh T. I. Tat`yana Il`inichna 1950-
Krasnyuk I. I. Ivan Ivanovich 1979-
Vasilenko I. A. Ivan Aleksandrovich 1948-
Fel`dman N. B. Nataliya Borisovna 1969-
Луценко С. В. Сергей Викторович 1957-
Громовых Т. И. Татьяна Ильинична 1950-
Краснюк И. И. Иван Иванович 1979-
Василенко И. А. Иван Александрович 1948-
Фельдман Н. Б. Наталия Борисовна 1969-
Antihepatotoxic Activity of Liposomal Silibinin
Текст визуальный непосредственный
BioNanoScience
Vol.8, Issue2 P. 581-586
2018
Статья
Drug delivery systems Hepatitis Liposomes Silibinin
Biochemistry Blood Drug products Flavonoids Liposomes Antihepatotoxic activity Drug delivery system Experimental animals Hepatitis Hepatoprotective effects Intragastric administration Silibinin Toxic hepatitis Drug delivery alanine aminotransferase aspartate aminotransferase carbon tetrachloride cholesterol cytochrome P450 liposome liver protective agent paracetamol phosphatidylcholine silibinin animal experiment animal model Article comparative study controlled study drug efficacy high performance liquid chromatography liposomal delivery liver protection mouse nonhuman particle size scanning electron microscopy toxic hepatitis
The liposomal form of silibinin was obtained, and its antihepatotoxic activity in mice was studied using a model of acute toxic hepatitis caused by injection of carbon tetrachloride or paracetamol. It was shown that the use of the drug in therapy or prevention regimens leads to normalization of levels of transaminases and total protein in the blood of experimental animals. The results of the study showed that liposomal silibinin when administered intravenously shows a more pronounced hepatoprotective effect compared to intragastric administration of free silibinin. Thus, the effectiveness of the therapeutic action of silibinin can be significantly increased by using its liposomal form. Liposomal drug, in contrast to native silibinin, can be injected directly into the blood that significantly increases its bioavailability. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.