Аннотация:
By the example of a model process of tryptophan photooxidation in the aqueous medium in the presence of a three-component photosensitizing complex (porphyrin photosensitizer-polyvinylpyrrolidone- chitosan, PPS-PVP-CT) in the temperature range of 20-40 °C, we have demonstrated a possibility of modification of such a process by selecting different molar ratios of the components in the reaction mixture. The actual objective of this selection is the formation of a certain PPS-PVP-CT composition in which PVP macromolecules would coordinate with PPS molecules and at the same time practically block the complex binding of PPS molecules with chitosan macromolecules. Such blocking allows utilization of the bactericidal properties of chitosan to a greater extent, since chitosan is known to depress the PPS photosensitizing activity in PPS-PVP-CT complexes when using those in photodynamic therapy (PDT). The optimal composition of photosensitizing complexes appears to be dependent on the temperature
Solovieva A. B.
Kardumian V. V.
Aksenova N. A. Nadezhda Anatolyevna 1979-
Belovolova L. V.
Glushkov M. V.
Bezrukov E. A. Evgenij Alekseevich 1975-
Sukhanov R. B. Roman Borisovich 1976-
Kotova S. L. Svetlana Leonidovna 1972-
Timashev P. S. Petr Sergeevich 1978-
Соловиева А. Б.
Кардумиан В. В.
Аксенова Н. А. Надежда Анатольевна 1979-
Беловолова Л. В.
Глушков М. В.
Безруков Е. А. Евгений Алексеевич 1975-
Суханов Р. Б. Роман Борисович 1976-
Котова С. Л. Светлана Леонидовна 1972-
Тимашев П. С. Петр Сергеевич 1978-
Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems
Текст визуальный непосредственный
Scientific Reports
Vol.8, Issue1 Num.8042
2018
Статья
By the example of a model process of tryptophan photooxidation in the aqueous medium in the presence of a three-component photosensitizing complex (porphyrin photosensitizer-polyvinylpyrrolidone- chitosan, PPS-PVP-CT) in the temperature range of 20-40 °C, we have demonstrated a possibility of modification of such a process by selecting different molar ratios of the components in the reaction mixture. The actual objective of this selection is the formation of a certain PPS-PVP-CT composition in which PVP macromolecules would coordinate with PPS molecules and at the same time practically block the complex binding of PPS molecules with chitosan macromolecules. Such blocking allows utilization of the bactericidal properties of chitosan to a greater extent, since chitosan is known to depress the PPS photosensitizing activity in PPS-PVP-CT complexes when using those in photodynamic therapy (PDT). The optimal composition of photosensitizing complexes appears to be dependent on the temperature