Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility
Demyashkin G. A.
Systems Biology in Reproductive Medicine
Vol.65, Issue1, P. 20-28
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1080/19396368.2018.1478470
Аннотация:
Inhibin B is one of the most significant serum markers of spermatogenesis, but its testicular expression has been poorly studied. Inhibin B sensitivity as well as the ability to reflect the level and condition of spermatogenesis and forecast certain changes in reproductive homeostasis in males is still a subject of active discussion. The purpose of this study is to examine the level of expression of inhibin B in cells of human seminiferous tubules in normal and in pathological spermatogenesis (idiopathic infertility) by revealing the proportion of immunostaining cells for inhibin B. The research conducted included analysis of testicular tissue samples taken from 82 males diagnosed with infertility and nonobstructive azoospermia. The influence of inhibin on the germ cells of men aged 22–35 been analyzed using the immunohistochemical method. According to the obtained results, high expression of inhibin can be detected both in Sertoli (98.0 ± 2.66) and Leydig (94.0 ± 1.55) cells in patien
Ключевые слова:
azoospermia; follicle stimulating hormone (FSH); idiopathic infertility; Inhibin B; testicular sperm extraction (TESE); testis biopsy
inhibin B; inhibin; inhibin B; adult; Article; azoospermia; controlled study; enzyme linked immunosorbent assay; germ cell; human; human tissue; idiopathic disease; immunohistochemistry; Leydig cell; male; male infertility; priority journal; protein expression; seminiferous tubule; Sertoli cell; spermatogenesis; spermatogonium; testis; case control study; male infertility; metabolism; pathology; seminiferous tubule; young adult; Adult; Case-Control Studies; Humans; Infertility, Male; Inhibins; Male; Seminiferous Tubules; Spermatogenesis; Young Adult
Язык текста: Английский
ISSN: 1939-6376
Demyashkin G. A.
Демяшкин Г. А.
Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility
Текст визуальный непосредственный
Systems Biology in Reproductive Medicine
Informa Healthcare
Vol.65, Issue1 P. 20-28
2019
Статья
azoospermia follicle stimulating hormone (FSH) idiopathic infertility Inhibin B testicular sperm extraction (TESE) testis biopsy
inhibin B inhibin inhibin B adult Article azoospermia controlled study enzyme linked immunosorbent assay germ cell human human tissue idiopathic disease immunohistochemistry Leydig cell male male infertility priority journal protein expression seminiferous tubule Sertoli cell spermatogenesis spermatogonium testis case control study male infertility metabolism pathology seminiferous tubule young adult Adult Case-Control Studies Humans Infertility, Male Inhibins Male Seminiferous Tubules Spermatogenesis Young Adult
Inhibin B is one of the most significant serum markers of spermatogenesis, but its testicular expression has been poorly studied. Inhibin B sensitivity as well as the ability to reflect the level and condition of spermatogenesis and forecast certain changes in reproductive homeostasis in males is still a subject of active discussion. The purpose of this study is to examine the level of expression of inhibin B in cells of human seminiferous tubules in normal and in pathological spermatogenesis (idiopathic infertility) by revealing the proportion of immunostaining cells for inhibin B. The research conducted included analysis of testicular tissue samples taken from 82 males diagnosed with infertility and nonobstructive azoospermia. The influence of inhibin on the germ cells of men aged 22–35 been analyzed using the immunohistochemical method. According to the obtained results, high expression of inhibin can be detected both in Sertoli (98.0 ± 2.66) and Leydig (94.0 ± 1.55) cells in patien