The role of neurosteroids metabolism in anticompulsive effect of pyrazole[c]pyridine derivative gizh-72
Кудряшов Н. В., Калинина Т. С., Касабов К. А., Шимширт А. А., Волкова А. В., Жмуренко Л. А., Воронина Т. А.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 2, С. 7-11
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-2-7-11
Аннотация:
There were studied the impact of selective antagonist of the mitochondrial translocator protein (TSPO 18 kDa) PK11195 (N-butan-2-yl-l-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; 1 or 3 mg/kg, i.p.) and 5α-reductase inhibitor finasteride (1.25; 2.5; 5 mg/kg, i.p.) on anticonvulsive effect of pyrazole[c]pyridine derivative GIZH-72 (4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-l//-pyrazolo[4,3-c]pyridin-3-one chloralhydrate, 20 mg/kg, i.p.) in marble burying test in C57BL/6 mice. It is established that PK11195 (1 or 3 mg/kg, i.p.) had no effects on both compulsive behavior of mice and anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Finasteride (2.5 or 5.0 mg/kg) decreased of compulsive behavior in the dose-dependent manner in C57BL/6 mice. Pretreatment with finasteride (2.5 or 5.0 mg/kg, i.p.) led to completely reduction of anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Thus, anticompulsive effect of GIZH-72 may depend on activity of 5α-reductase, but not TSPO 18 kDa. © 201
Ключевые слова:
C57BL/6 mice; Finasteride; GIZH-72; Neurosteroids; Obsessive compulsive disorder; PK11195
4,6 dimethyl 2 (4 chlorophenyl) 2,3 dihydro 1h pyrazolo[4,3 c]pyridin 3 one; carrier protein; finasteride; gizh 72; n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide; neurosteroid; pyrazole derivative; pyridine derivative; steroid 5alpha reductase; unclassified drug; animal experiment; animal model; anticompulsive effect; Article; biological activity; compulsion; dose response; drug effect; marble burying test; mouse; nonhuman; steroid metabolism
Язык текста: Русский
ISSN: 0869-2092
Кудряшов Н. В. Никита Викторович 1989-
Калинина Т. С.
Касабов К. А.
Шимширт А. А.
Волкова А. В.
Жмуренко Л. А.
Воронина Т. А.
Kudryashov N. V. Nikita Viktorovich 1989-
Kalinina T. S.
Kasabov K. A.
Shimshirt A. A.
Volkova A. V.
Zhmurenko L. A.
Voronina T. A.
The role of neurosteroids metabolism in anticompulsive effect of pyrazole[c]pyridine derivative gizh-72
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 2 С. 7-11
2018
Статья
C57BL/6 mice Finasteride GIZH-72 Neurosteroids Obsessive compulsive disorder PK11195
4,6 dimethyl 2 (4 chlorophenyl) 2,3 dihydro 1h pyrazolo[4,3 c]pyridin 3 one carrier protein finasteride gizh 72 n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide neurosteroid pyrazole derivative pyridine derivative steroid 5alpha reductase unclassified drug animal experiment animal model anticompulsive effect Article biological activity compulsion dose response drug effect marble burying test mouse nonhuman steroid metabolism
There were studied the impact of selective antagonist of the mitochondrial translocator protein (TSPO 18 kDa) PK11195 (N-butan-2-yl-l-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; 1 or 3 mg/kg, i.p.) and 5α-reductase inhibitor finasteride (1.25; 2.5; 5 mg/kg, i.p.) on anticonvulsive effect of pyrazole[c]pyridine derivative GIZH-72 (4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-l//-pyrazolo[4,3-c]pyridin-3-one chloralhydrate, 20 mg/kg, i.p.) in marble burying test in C57BL/6 mice. It is established that PK11195 (1 or 3 mg/kg, i.p.) had no effects on both compulsive behavior of mice and anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Finasteride (2.5 or 5.0 mg/kg) decreased of compulsive behavior in the dose-dependent manner in C57BL/6 mice. Pretreatment with finasteride (2.5 or 5.0 mg/kg, i.p.) led to completely reduction of anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Thus, anticompulsive effect of GIZH-72 may depend on activity of 5α-reductase, but not TSPO 18 kDa. © 201