Microbiological oropharyngeal patterns in patients with different phenotypes of chronic obstructive pulmonary disease
Karnaushkina M. A., Fedosenko S. V., Sazonov A. E., Petrov V. A., Ovsyannikov D. Y., Ogorodova L. M.
Современные технологии в медицине
Vol.10, Issue2, P. 101-107
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17691/stm2018.10.2.11
Аннотация:
Persistent bronchial inflammation in chronic obstructive pulmonary disease (COPD) is considered the cause of ventilation disorders and related contamination with conditionally pathogenic microorganisms; the latter can proceed and transform into a full infection, which can aggravate and exacerbate COPD. The aim of the study was to evaluate the relations between the oropharyngeal microbiota in patients with COPD and the clinical, functional, and prognostic parameters of the disease. Materials and Methods. 64 patients with COPD were included in the study; the participants were scheduled to visit our clinic on two occasions. In the first visit, their medical history was studied in detail and the major examination procedures were conducted. Those included an assessment of the respiratory function, the 6-minute walk test, the degree of dyspnea by the Medical Research Council scale, body plethysmography, the diffusion capacity of the lungs, and a chest CT scan. The second visit took place 12
Ключевые слова:
COPD; COPD phenotypes; Oropharyngeal microbiota; Sequencing; Severity
beta 2 adrenergic receptor stimulating agent; cholinergic receptor blocking agent; glucocorticoid; RNA 16S; Actinobacteria; adult; antibiotic therapy; Article; chronic bronchitis; chronic obstructive lung disease; clinical evaluation; computer assisted tomography; dyspnea; emphysema; Firmicutes; forced expiratory volume; gene sequence; human; lung diffusion capacity; major clinical study; middle aged; mouth flora; nonhuman; oropharyngeal microbiota; oropharyngeal swab; phenotype; plethysmography; Prevotella; prognosis; prospective study; Proteobacteria; respiratory function; six minute walk test; Streptococcus; throat culture; Veillonella
Язык текста: Английский
ISSN: 2076-4243
Karnaushkina M. A. Mariya Aleksandrovna 1968-
Fedosenko S. V.
Sazonov A. E.
Petrov V. A.
Ovsyannikov D. Y.
Ogorodova L. M.
Карнаушкина М. А. Мария Александровна 1968-
Федосенко С. В.
Сазонов А. Е.
Петров В. А.
Овсянников Д. Y.
Огородова Л. М.
Microbiological oropharyngeal patterns in patients with different phenotypes of chronic obstructive pulmonary disease
Текст визуальный непосредственный
Современные технологии в медицине
Нижегородская государственная медицинская академия
Vol.10, Issue2 P. 101-107
2018
Статья
COPD COPD phenotypes Oropharyngeal microbiota Sequencing Severity
beta 2 adrenergic receptor stimulating agent cholinergic receptor blocking agent glucocorticoid RNA 16S Actinobacteria adult antibiotic therapy Article chronic bronchitis chronic obstructive lung disease clinical evaluation computer assisted tomography dyspnea emphysema Firmicutes forced expiratory volume gene sequence human lung diffusion capacity major clinical study middle aged mouth flora nonhuman oropharyngeal microbiota oropharyngeal swab phenotype plethysmography Prevotella prognosis prospective study Proteobacteria respiratory function six minute walk test Streptococcus throat culture Veillonella
Persistent bronchial inflammation in chronic obstructive pulmonary disease (COPD) is considered the cause of ventilation disorders and related contamination with conditionally pathogenic microorganisms; the latter can proceed and transform into a full infection, which can aggravate and exacerbate COPD. The aim of the study was to evaluate the relations between the oropharyngeal microbiota in patients with COPD and the clinical, functional, and prognostic parameters of the disease. Materials and Methods. 64 patients with COPD were included in the study; the participants were scheduled to visit our clinic on two occasions. In the first visit, their medical history was studied in detail and the major examination procedures were conducted. Those included an assessment of the respiratory function, the 6-minute walk test, the degree of dyspnea by the Medical Research Council scale, body plethysmography, the diffusion capacity of the lungs, and a chest CT scan. The second visit took place 12