Modern notions concerning the mechanisms of nitrate tolerance development: Prospects of coenzyme Q10 administration
Абдуллаев С. П., Козаева Л. П., Медведев О. С.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 2, С. 33-43
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.30906/0869-2092-2018-81-2-33-41
Аннотация:
Organic nitrates are widely used in clinical treatment of cardiovascular diseases, but the problem of developing tolerance during long-term therapy remains urgent. The analysis of published works shows that the nitrate tolerance development is caused by various mechanisms, including disturbances in neurohormonal regulation of vessel tonus and biochemical pathways of realization of the nitrate effect. This review summarizes the current notions of the mechanisms of nitrate tolerance development and vascular changes during nitrate drug application and analyzes potential efficiency of using coenzyme Q10 for preventing the development of nitrate tolerance and nitrate-induced endothelial dysfunction. © 2018 Izdatel'stvo Meditsina. All rights reserved.
Ключевые слова:
Coenzyme Q10; Endothelial dysfunction; Nitrate tolerance; Organic nitrates
nitrate; ubidecarenone; drug tolerance; endothelial dysfunction; human; Review
Язык текста: Русский
ISSN: 0869-2092
Абдуллаев С. П. Ш.П.
Козаева Л. П. Лариса Петровна 1971-
Медведев О. С.
Abdullaev S. P. Sh.P.
Kozaeva L. P. Larisa Petrovna 1971-
Medvedev O. S.
Modern notions concerning the mechanisms of nitrate tolerance development: Prospects of coenzyme Q10 administration
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 2 С. 33-43
2018
Обзор
Coenzyme Q10 Endothelial dysfunction Nitrate tolerance Organic nitrates
nitrate ubidecarenone drug tolerance endothelial dysfunction human Review
Organic nitrates are widely used in clinical treatment of cardiovascular diseases, but the problem of developing tolerance during long-term therapy remains urgent. The analysis of published works shows that the nitrate tolerance development is caused by various mechanisms, including disturbances in neurohormonal regulation of vessel tonus and biochemical pathways of realization of the nitrate effect. This review summarizes the current notions of the mechanisms of nitrate tolerance development and vascular changes during nitrate drug application and analyzes potential efficiency of using coenzyme Q10 for preventing the development of nitrate tolerance and nitrate-induced endothelial dysfunction. © 2018 Izdatel'stvo Meditsina. All rights reserved.