Molecular and cell mechanisms of the stress-protective activity of adaptogenic phytopreparation kardecaim on the background of emotional stress
Алексеева Е. А., Малyшев И. Y., Шантанова Л. Н., Николаев С. М., Карева Е. Н.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 2, С. 17-20
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-2-17-20
Аннотация:
We have studied the adaptogenic properties of Kardecaim phytopreparation based on dry extracts derived from Inula helenium L., Zingiber officinale Roscoe, Elletaria cardamomum (L.) Maton., and Caragaha spinose (L.) Wall, ex Homem, which contain phenolic compounds and terpenoids. A course of preventive administration of Kardecaim to white rats in a dose of 100 mg/kg for 7 days before the induction of acute emotional stress produced stress-protective effect by preventing the development of catabolic signs of Selye's triad in animal inner organs, including the thymus involution (40[%] lower than in control); degree of hemorrhagic and ulcerative defects in the stomach mucosa (5 times less than reference gastroprotector effect), and somewhat less pronounced effect on the stress-induced hypertrophy of adrenal glands, yet comparable to the effect of reference preparation (eleutherococcus extract). It was shown that the increase in the resistance to stress under the action of Kardecaim was due t
Ключевые слова:
Emotional stress; Heat shock proteins; NO system; Plant based adaptogens
Eleutherococcus extract; heat shock protein 70; kardecaim; plant extract; unclassified drug; acute stress; acute stress disorder; adrenal hyperplasia; animal experiment; animal model; Article; Caragana spinose; controlled study; disease severity; drug mechanism; Elletaria cardamomum; emotional stress; ginger; Inula; Inula helenium; medicinal plant; nonhuman; protein content; rat; stomach hemorrhage; stomach mucosa; stomach ulcer; thymus
Язык текста: Русский
ISSN: 0869-2092
Алексеева Е. А.
Малyшев И. Y. И.Ю.
Шантанова Л. Н.
Николаев С. М.
Карева Е. Н. Елена Николаевна 1961-
Alekseeva E. A.
Malyshev I. Y. I.Yu.
Shantanova L. N.
Nikolaev S. M.
Kareva E. N. Elena Nikolaevna 1961-
Molecular and cell mechanisms of the stress-protective activity of adaptogenic phytopreparation kardecaim on the background of emotional stress
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 2 С. 17-20
2018
Статья
Emotional stress Heat shock proteins NO system Plant based adaptogens
Eleutherococcus extract heat shock protein 70 kardecaim plant extract unclassified drug acute stress acute stress disorder adrenal hyperplasia animal experiment animal model Article Caragana spinose controlled study disease severity drug mechanism Elletaria cardamomum emotional stress ginger Inula Inula helenium medicinal plant nonhuman protein content rat stomach hemorrhage stomach mucosa stomach ulcer thymus
We have studied the adaptogenic properties of Kardecaim phytopreparation based on dry extracts derived from Inula helenium L., Zingiber officinale Roscoe, Elletaria cardamomum (L.) Maton., and Caragaha spinose (L.) Wall, ex Homem, which contain phenolic compounds and terpenoids. A course of preventive administration of Kardecaim to white rats in a dose of 100 mg/kg for 7 days before the induction of acute emotional stress produced stress-protective effect by preventing the development of catabolic signs of Selye's triad in animal inner organs, including the thymus involution (40[%] lower than in control); degree of hemorrhagic and ulcerative defects in the stomach mucosa (5 times less than reference gastroprotector effect), and somewhat less pronounced effect on the stress-induced hypertrophy of adrenal glands, yet comparable to the effect of reference preparation (eleutherococcus extract). It was shown that the increase in the resistance to stress under the action of Kardecaim was due t