The effect of different tb drugs and antimicrobial agents on the efficiency of treatment of tuberculosis patients with multiple drug resistance
Vasilyeva I. A., Samoylova A. G., Ловачева О. В., Черноусова Л. Н., Bagdasaryan T. R.
Туберкулез и болезни легких
Т. 95, Вып. 10, С. 9-15
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.21292/2075-1230-2017-95-10-9-15
Аннотация:
Objective of the study: to study the effect of specific TB drugs and antimicrobial agents constituting chemotherapy regimens on the efficiency of treatment of tuberculosis patients with various patterns of multiple drug resistance Subjects and Methods. 412 pulmonary tuberculosis patients with bacillary excretion and various patterns of multiple drug resistance were enrolled into the study (117 patients with MDR TB (non pre-XDR and non-XDR); 120 patients with pre-XDR TB and 175 with XDR TB) Patients in the subgroups were compatible regarding sex and age The patients were prescribed regimens including 5-6 drugs in accordance with their drug resistance pattern The time of sputum conversion (by culture) versus the year of treatment was selected as a surrogate endpoint The effect of specific TB drugs and antimicrobial agents on treatment efficiency was assessed through calculation of odds ratio (OR) of achieving a surrogate endpoint in the patients receiving and not receiving a certain drug
Ключевые слова:
Bedaquiline; Fluoruquinolones; Linezolid; MDR TB; Pulmonary tuberculosis; Tuberculosis chemotherapy; XDR TB
Язык текста: Русский
ISSN: 2542-1506
Vasilyeva I. A. Irina Anatolyevna 1966-
Samoylova A. G.
Ловачева О. В.
Черноусова Л. Н.
Bagdasaryan T. R.
Васильева И. А. Ирина Анатольевна 1966-
Самоyлова А. Г.
Lovacheva O. V.
Chernousova L. N.
Багдасарян Т. Р.
The effect of different tb drugs and antimicrobial agents on the efficiency of treatment of tuberculosis patients with multiple drug resistance
Текст визуальный непосредственный
Туберкулез и болезни легких
Нью Терра
Т. 95, Вып. 10 С. 9-15
2017
Статья
Bedaquiline Fluoruquinolones Linezolid MDR TB Pulmonary tuberculosis Tuberculosis chemotherapy XDR TB
Objective of the study: to study the effect of specific TB drugs and antimicrobial agents constituting chemotherapy regimens on the efficiency of treatment of tuberculosis patients with various patterns of multiple drug resistance Subjects and Methods. 412 pulmonary tuberculosis patients with bacillary excretion and various patterns of multiple drug resistance were enrolled into the study (117 patients with MDR TB (non pre-XDR and non-XDR); 120 patients with pre-XDR TB and 175 with XDR TB) Patients in the subgroups were compatible regarding sex and age The patients were prescribed regimens including 5-6 drugs in accordance with their drug resistance pattern The time of sputum conversion (by culture) versus the year of treatment was selected as a surrogate endpoint The effect of specific TB drugs and antimicrobial agents on treatment efficiency was assessed through calculation of odds ratio (OR) of achieving a surrogate endpoint in the patients receiving and not receiving a certain drug