Аннотация:
Background: A low protein diet (LPD) with essential amino acid ketoanalogue supplementation (KA) may contribute in improving of chronic kidney disease (CKD), while the exact mechanisms of KA’s effect are not established yet. We have conducted a prospective, randomized, controlled comparative study of LPD + KA and LPD alone in relation to serum Klotho, FGF-23 levels in CKD patients. Methods: 79 non-diabetic CKD 3b–4 stage patients, compliant with LPD diet (0.6 g/kg of body weight/day), had been selected. The patients were randomized into two groups. The first group (42 patients) received LPD + КA. The second group (37 patients) continued the LРD alone. In addition to routine tests, serum Klotho, FGF-23 levels, as well as bioimpedance analysis, sphygmography (stiffness (augmentation) indices (AI), central (aortal) blood pressure) with a «SphygmaCor» device; echocardiography (valvular calcification score (VCS) and LVMMI), were performed. Results: There were body mass indices’ decrease (p
Milovanova L. Yu. Lyudmila Yuryevna 1973-
Fomin V. V. Viktor Viktorovich 1978-
Moiseev S. V. Sergej Valentinovich 1960-
Taranova M. V. Marina Vladimirovna 1957-
Milovanov Yu. S. Yurij Sergeevich 1944-
Lysenko (. L. (Kozlovskaya) L.
Kozlov V. V. Vasilij Vladimirovich 1974-
Kozevnikova E.
Milovanova S. Yu. Svetlana Yuryevna 1975-
Lebedeva M. V. Marina Valeryevna 1966-
Reshetnikov V. A. Vladimir Anatolyevich 1960-
Милованова Л. Ю. Людмила Юрьевна 1973-
Фомин В. В. Виктор Викторович 1978-
Моисеев С. В. Сергей Валентинович 1960-
Таранова М. В. Марина Владимировна 1957-
Милованов Ю. С. Юрий Сергеевич 1944-
Лyсенко (. Л. (Козловскайа) Л.
Козлов В. В. Василий Владимирович 1974-
Козевникова Е.
Милованова С. Ю. Светлана Юрьевна 1975-
Лебедева М. В. Марина Валерьевна 1966-
Решетников В. А. Владимир Анатольевич 1960-
Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b–4 stages chronic кidney disease patients: a randomized pilot study
Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b–4 stages chronic...
Текст визуальный непосредственный
Clinical and Experimental Nephrology
Springer-Verlag Tokyo Inc.
Vol.22, Issue6 P. 1351-1359
2018
Статья
Cardiac remodeling Cardiovascular calcification Chronic kidney disease Essential amino acid ketoanalogues Fibroblast growth factor-23 (FGF-23) Serum alpha-Klotho (sKlotho)
essential amino acid fibroblast growth factor 23 Klotho protein beta glucuronidase essential amino acid fibroblast growth factor fibroblast growth factor 23 Klotho protein adult Article augmentation index blood pressure chronic kidney failure comparative study controlled study echocardiography female follow up glomerulus filtration rate human kidney function major clinical study male nutritional status prospective study protein restriction randomized controlled trial blood blood vessel calcification chronic kidney failure complication heart left ventricle hypertrophy malnutrition pilot study Amino Acids, Essential Diet, Protein-Restricted Female Fibroblast Growth Factors Glucuronidase Humans Hypertrophy, Left Ventricular Male Malnutrition Pilot Projects Prospective Studies Renal Insufficiency, Chronic Vascular Calcification
Background: A low protein diet (LPD) with essential amino acid ketoanalogue supplementation (KA) may contribute in improving of chronic kidney disease (CKD), while the exact mechanisms of KA’s effect are not established yet. We have conducted a prospective, randomized, controlled comparative study of LPD + KA and LPD alone in relation to serum Klotho, FGF-23 levels in CKD patients. Methods: 79 non-diabetic CKD 3b–4 stage patients, compliant with LPD diet (0.6 g/kg of body weight/day), had been selected. The patients were randomized into two groups. The first group (42 patients) received LPD + КA. The second group (37 patients) continued the LРD alone. In addition to routine tests, serum Klotho, FGF-23 levels, as well as bioimpedance analysis, sphygmography (stiffness (augmentation) indices (AI), central (aortal) blood pressure) with a «SphygmaCor» device; echocardiography (valvular calcification score (VCS) and LVMMI), were performed. Results: There were body mass indices’ decrease (p